Mast cell tryptase promotes breast cancer migration and invasion.
Mast cell tryptase promotes breast cancer migration and invasion.
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DOI：
10.3892/or_00000676
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发表时间：
2010-03
期刊：
影响因子：
4.2
通讯作者：
Meng Xiang;Yiping Gu;F. Zhao;Hong Lu;Sifen chen;L. Yin
中科院分区：
文献类型：
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作者：
Meng Xiang;Yiping Gu;F. Zhao;Hong Lu;Sifen chen;L. Yin
据报道，乳腺瘤周组织中典型酶阳性肥大细胞的数量明显较多。然而，类胰蛋白酶在肿瘤生长和转移中的意义尚不清楚。通过免疫组织化学对手术乳腺癌样本中的类胰蛋白酶进行染色。体外观察类胰蛋白酶对乳腺癌增殖、侵袭和迁移的影响。我们发现瘤周组织中的类胰蛋白酶明显多于正常乳腺组织。类胰蛋白酶增加与较高的肿瘤分级和更多的淋巴结转移相关。类胰蛋白酶随着基质金属蛋白酶-2的激活而促进乳腺癌细胞的侵袭和迁移。类胰蛋白酶不影响细胞的增殖。我们的结果表明类胰蛋白酶促进乳腺癌迁移和侵袭。
It has been reported that the number of typtase-positive mast cells was significantly greater in breast peritumoral tissue. However, the significance of tryptase in tumor growth and metastasis is unknown. Tryptase in surgical breast cancer samples was stained by immunohistochemistry. The effects of tryptase on breast cancer proliferation, invasion and migration were observed in vitro. We found significantly more tryptase in peritumoral tissue than in normal breast tissue. The increased tryptase was associated with higher tumor grade and more lymph node metastasis. Tryptase promoted the invasion and migration of breast cancer cells along with activation of matrix metalloproteinase-2. Tryptase did not affect the proliferation of the cells. Our results indicate that tryptase promotes breast cancer migration and invasion.