HALOPERIDOL AND CLOZAPINE DECREASE S100B RELEASE FROM GLIAL CELLS
HALOPERIDOL AND CLOZAPINE DECREASE S100B RELEASE FROM GLIAL CELLS
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DOI：
10.1016/j.neuroscience.2010.03.010
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发表时间：
2010-06-02
期刊：
影响因子：
3.3
通讯作者：
Keilhoff, G.
中科院分区：
文献类型：
--
作者：
Steiner, J.;Schroeter, M. L.;Keilhoff, G.
最近的荟萃分析显示，精神分裂症患者的血清和脑脊液中 S100B 水平持续升高。这一发现归因于神经胶质病理学，因为 S100B 由星形胶质细胞和少突胶质细胞产生。然而，S100B 可能同样与精神分裂症相关的神经胶质细胞以及脂肪细胞能量供应和葡萄糖代谢紊乱有关。抗精神病药物对 S100B 水平的影响尚不清楚，一些研究表明，使用这些药物治疗实际上可能导致精神分裂症患者中观察到的 S100B 水平升高。在本研究中，我们探讨了典型抗精神病药物氟哌啶醇和非典型原型药物氯氮平对星形胶质细胞C6细胞和少突胶质细胞OLN-93细胞释放S100B的影响。由于精神分裂症与能量代谢紊乱之间存在关联，我们评估了这些药物在基础条件（BC）与血清和葡萄糖剥夺（SGD）条件下的效果。我们发现，在体外 BC 和 SGD 下，在与这些药物的假定治疗剂量范围相对应的组织浓度下，用氟哌啶醇和氯氮平处理 C6 和 OLN-93 细胞减少了 C6 和 OLN-93 细胞中 S100B 的释放。这些数据表明，精神分裂症患者体液中 S100B 水平升高是正常化的，而不是由于抗精神病药物对神经胶质细胞的影响而增加。 (C) 2010 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Recent meta-analyses showed consistently elevated levels of S100B in serum and cerebrospinal fluid of schizophrenic patients. This finding has been attributed to glial pathology because S100B is produced by astrocytes and oligodendrocytes. However, S100B may be likewise associated with schizophrenia-related disturbances in glial cell as well as adipocyte energy supply and glucose metabolism. The influence of antipsychotic drugs on S100B levels remains unclear, and some studies have suggested that treatment with these drugs may actually contribute to the elevated S100B levels observed in schizophrenic patients. In this study, we explored the effects of the typical antipsychotic haloperidol and the atypical prototype drug clozapine on the release of S100B by astrocytic C6 cells and oligodendrocytic OLN-93 cells. Because of the association between schizophrenia and disturbances in energy metabolism, we assessed the effects of these drugs under basal condition (BC) compared to serum and glucose deprivation (SGD). We found that treatment of C6 and OLN-93 cells with haloperidol and clozapine reduced the release of S100B from C6 and OLN-93 cells under BC and SGD in vitro at a tissue concentration corresponding to the assumed therapeutic dose range of these drugs. These data suggest that elevated levels of S100B in bodily fluids of schizophrenic patients are normalized rather than increased by the effects of antipsychotic drugs on glial cells. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.