Evidence that parent-of-origin affects birth-weight reductions at high altitude
Evidence that parent-of-origin affects birth-weight reductions at high altitude
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DOI：
10.1002/ajhb.20784
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发表时间：
2008-09-01
影响因子：
2.9
通讯作者：
Moore, Lorna G.
中科院分区：
文献类型：
--
作者：
Bennett, Adam;Sain, Stephen R.;Moore, Lorna G.
低氧对胎儿生长发育有深远的抑制作用，降低出生体重，增加死亡风险。多代高海拔地区的人口相对不会受到出生体重下降的影响，这让我们假设遗传因素参与其中。我们询问高海拔和低海拔祖先的数量是否影响高海拔地区的出生体重，特别是这种影响是否受到父母原籍效应(即基因组印记)的影响。对玻利维亚拉巴斯(3600米)高(安第斯)或低(欧洲)海拔血统的1343名连续单胎分娩的医疗记录进行了审查。父母的姓氏被用来将祖先归类为安第斯、欧洲、梅斯蒂佐(“混合”)或它们的某种组合。人口血统对出生体重的影响通过分类、条件线性回归来确定。有两个安第斯山脉父母的高原出生的婴儿比他们的欧洲同龄人多重252克，保护作用与安第斯血统成正比，与母亲的产次、体型、吸烟或社会经济地位无关。与母系相比，父系遗传使出生体重增加了81g。我们的结论是，土著高海拔血统以剂量依赖的方式保护胎儿免受缺氧所致的胎儿生长减少，这与遗传因素的参与是一致的。此外，考虑到母系传播受到限制，而父系传播促进胎儿生长，其中一些涉及的基因似乎受到了父母原籍效应的影响。
Hypoxia exerts a profound depressant effect on fetal growth, lowering birth weight, and raising mortality risk. Multigenerational high-altitude populations are relatively protected from this birth-weight decline, leading us to hypothesize that genetic factors were involved. We asked if the amount of high- versus low-altitude ancestry influenced birth weight at high altitude and, specifically, whether such influences were affected by parent-of-origin effects (i.e., genomic imprinting). Medical records were reviewed from 1,343 consecutive, singleton deliveries in La Paz, Bolivia (3,600 m) of high- (Andean) or low- (European) altitude ancestry. Parental surnames were used to classify ancestry as Andean, European, Mestizo ("mixed") or some combination thereof. The effects of population ancestry on birth weight were determined by categorical, conditional linear regression. Babies born at altitude with two Andean parents weighed 252 g more than their European counterparts, with the protective effect being proportional to the amount of Andean parentage and independent of maternal parity, body size, smoking, or socioeconomic status. Paternal compared with maternal transmission raised birth weight 81 g for a given ancestry group. We concluded that indigenous high-altitude ancestry protected against hypoxia-associated fetal growth reduction in a dose-dependent fashion consistent with the involvement of genetic factors. Further, some of the genes involved appeared to be influenced by parent-of-origin effects, given that maternal transmission restricted and paternal transmission enhanced fetal growth.