Monoamine oxidases as sources of oxidants in the heart.
Monoamine oxidases as sources of oxidants in the heart.
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DOI：
10.1016/j.yjmcc.2013.12.032
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发表时间：
2014-08
影响因子：
5
通讯作者：
Di Lisa, Fabio
中科院分区：
文献类型：
--
作者：
Kaludercic, Nina;Mialet-Perez, Jeanne;Paolocci, Nazareno;Parini, Angelo;Di Lisa, Fabio
关键词：
氧化应激可以在线粒体内的多个位点产生。其中，单胺氧化酶（MAO）被描述为一个重要来源。 MAO 是线粒体黄酶，负责儿茶酚胺、血清素和生物胺的氧化脱氨，在此过程中它们产生 H2O2 和醛中间体。 MAO 在心血管病理生理学中的作用最近才引起一些关注，因为已经证明 H2O2 和醛都可能以线粒体功能为目标，从而影响心肌的功能和活力。在本综述中，我们将讨论 MAO 在儿茶酚胺和血清素清除以及与心脏结构和功能相关的循环中的作用。将讨论每种 MAO 亚型（MAO-A 或 -B）与线粒体功能障碍和心肌损伤的相关贡献。最后，我们将检查它们的药理学或遗传抑制的有益影响以及在 MAO 敲除小鼠中基线观察到的潜在不利影响，以及它们在心肌细胞水平上过度表达后的有害影响。
Oxidative stress can be generated at several sites within the mitochondria. Among these, monoamine oxidases (MAO) have been described as a prominent source. MAO are mitochondrial flavoenzymes responsible for the oxidative deamination of catecholamines, serotonin and biogenic amines, and during this process they generate H2O2 and aldehyde intermediates. The role of MAO in cardiovascular pathophysiology has only recently gathered some attention since it has been demonstrated that both H2O2 and aldehydes may target mitochondrial function and consequently affect function and viability of the myocardium. In the present review, we will discuss the role of MAO in catecholamine and serotonin clearance and cycling in relation to cardiac structure and function. The relevant contribution of each MAO isoform (MAO-A or -B) will be discussed in relation to mitochondrial dysfunction and myocardial injury. Finally, we will examine both beneficial effects of their pharmacological or genetic inhibition along with potential adverse effects observed at baseline in MAO knockout mice, as well as the deleterious effects following their over-expression specifically at cardiomyocyte level.
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影响因子：
11.4
作者：
Bueno, OF;De Windt, LJ;Molkentin, JD
通讯作者：
Molkentin, JD
影响因子：
4.7
作者：
Cao, Xia;Rui, Lewei;Mousseau, Darrell D.
通讯作者：
Mousseau, Darrell D.
影响因子：
--
作者：
Bortolato, Marco;Shih, Jean C.
通讯作者：
Shih, Jean C.
DOI：
10.1016/0160-5402(82)90025-0
发表时间：
1982-01-01
期刊：
JOURNAL OF PHARMACOLOGICAL METHODS
影响因子：
--
作者：
DORRIS, RL
通讯作者：
DORRIS, RL
影响因子：
4.8
作者：
Chen, K;Holschneider, DP;Shih, JC
通讯作者：
Shih, JC