Wireless, battery-free, flexible, miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy
Wireless, battery-free, flexible, miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy
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DOI：
10.1126/scitranslmed.aau1643
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发表时间：
2018-12-05
影响因子：
17.1
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Heo, Seung Yun;Kim, Jeonghyun;Rogers, John A.
暴露于电磁辐射会对人体健康产生深远的影响。来自太阳的紫外线辐射会导致皮肤癌。蓝光会影响人体的褪黑激素昼夜节律。同时，受控量的电磁辐射具有有益的用途。紫外线治疗各种炎症性皮肤病，蓝光光疗是新生儿黄疸的护理标准。尽管在这些情况下对暴露的定量测量很重要，但由于体积、重量、成本和准确性等一系列不利因素，目前的系统在实验室以外的适用性有限。我们提出了光学计量方法，光电设计和无线操作模式，作为微型，低成本和无电池设备的基础，在多个波长下进行精确的剂量测定。这些平台使用具有近场通信功能的片上系统、射频天线、光电二极管、超级电容器和晶体管，以利用连续累积机制进行测量。实验和计算研究的各个组件，集体系统，和性能参数突出的工作原理和设计考虑。对人类参与者的评估监测了户外活动期间的太阳紫外线暴露，在新生儿重症监护病房的蓝光光疗期间捕获了瞬时和累积暴露，并跟踪了季节性情感障碍光疗的光照。该剂量测定平台的多功能应用为消费者和医疗提供者提供了在电磁频谱上调制光暴露的手段，其方式既可以降低过度暴露背景下的风险，又可以优化光疗背景下的益处。
Exposure to electromagnetic radiation can have a profound impact on human health. Ultraviolet (UV) radiation from the sun causes skin cancer. Blue light affects the body's circadian melatonin rhythm. At the same time, electromagnetic radiation in controlled quantities has beneficial use. UV light treats various inflammatory skin conditions, and blue light phototherapy is the standard of care for neonatal jaundice. Although quantitative measurements of exposure in these contexts are important, current systems have limited applicability outside of laboratories because of an unfavorable set of factors in bulk, weight, cost, and accuracy. We present optical metrology approaches, optoelectronic designs, and wireless modes of operation that serve as the basis for miniature, low-cost, and battery-free devices for precise dosimetry at multiple wavelengths. These platforms use a system on a chip with near-field communication functionality, a radio frequency antenna, photodiodes, supercapacitors, and a transistor to exploit a continuous accumulation mechanism for measurement. Experimental and computational studies of the individual components, the collective systems, and the performance parameters highlight the operating principles and design considerations. Evaluations on human participants monitored solar UV exposure during outdoor activities, captured instantaneous and cumulative exposure during blue light phototherapy in neonatal intensive care units, and tracked light illumination for seasonal affective disorder phototherapy. Versatile applications of this dosimetry platform provide means for consumers and medical providers to modulate light exposure across the electromagnetic spectrum in a way that can both reduce risks in the context of excessive exposure and optimize benefits in the context of phototherapy.