Hair dye use and risk of human cancer.
Hair dye use and risk of human cancer.
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DOI：
10.2741/397
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Zheng T
中科院分区：
文献类型：
--
作者：
Zhang Y;Kim C;Zheng T
超过50%的成年人会在一生中的某个时候使用染发剂。染发剂由各种化学物质组成，这些化学物质的组成因染发剂类型而异。化学品对苯二胺和氨基苯在实验研究中被认为是可能的致癌物或诱变剂。科学界一直对这种潜在的公共卫生影响感兴趣，并在此总结了已发表的流行病学研究结果。目前的证据提供了有限的证据，个人染发剂的使用和人类癌症风险之间的关联，除了造血系统癌症的可能性，在较小程度上，膀胱癌。风险似乎受到使用时间和特定遗传多态性的影响。未来的研究应探讨潜在的基因和环境的相互作用，以评估可能的遗传易感性。在未来的研究中还应考虑几个方法学问题，包括完成染发剂使用信息，如染发剂产品使用的时间、持续时间、频率和类型。
Over 50% of the adult population will use hair dyes at some point in their lifetimes. Hair dyes consist of various chemicals and the composition of these chemicals vary by hair dye types. Chemicals p-phenylenediamine and aminophenyl have been suggested as possible carcinogens or mutagens in experimental studies. The scientific community has been interested in this potential public health impact and the results of published epidemiological studies are summarized here. The current evidence provides limited evidences on the association between personal hair dye use and human cancer risk, except for the possibility of hematopoietic cancers and to a lesser extent, bladder cancer. Risk appears to be affected by time period of use and by specific genetic polymorphisms. Future studies should investigate potential gene and environment interaction to assess possible genetic susceptibility. Several methodological issues should also be considered in future studies including completed hair dye use information such as on timing, duration, frequency and type of hair dye product use.