Directional diffusion in relapsing-remitting multiple sclerosis: A possible in vivo signature of Wallerian degeneration
Directional diffusion in relapsing-remitting multiple sclerosis: A possible in vivo signature of Wallerian degeneration
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DOI：
10.1002/jmri.10379
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发表时间：
2003-10-01
影响因子：
4.4
通讯作者：
Pelletier, D
中科院分区：
文献类型：
--
作者：
Henry, RG;Oh, JM;Pelletier, D
目的：为了研究扩散张量特征值在评价复发缓解型多发性硬化症患者的正常表现脑区中的作用，对18名复发缓解型多发性硬化症患者和15名年龄匹配的正常对照者的扩散张量特征值进行了研究。各向同性表观扩散在所有区域中增加。然而，各向异性降低仅在各向异性高的区域显著，包括胼胝体和内囊，这是由于弥散张量特征值增加，对应于弥散横向于纤维，而沿着纤维没有显著增加。这种扩散张量特征值变化的特征模式以前在沃勒变性的情况下已经观察到。低各向异性区域对应于灰质和灰色/白色界面区域。由于纤维束的方向是不确定的低各向异性的区域，这种扩散变化的特征模式是不可检测的，在这些regions.Conclusion：检查扩散张量特征向量可以提供洞察扩散观察到的变化和沃勒变性的签名在正常出现的白色物质的复发缓解型多发性硬化症患者。
Purpose: To examine the role of directional dependence of the apparent diffusion coefficients in the evaluation of normal-appearing brain regions of patients with relapsing-remitting multiple sclerosis.Materials and Methods: The role of diffusion tensor eigenvalues was investigated in the normal-appearing brain regions for 18 patients with relapsing-remitting multiple sclerosis and 15 age-matched normal controls.Results: The isotropic apparent diffusion was increased in all regions. However, reduced anisotropy was significant only in regions with high anisotropy, including the corpus callosum and the internal capsule, and was due to increased diffusion tensor eigenvalues corresponding to diffusion transverse to the fibers without significant increase along the fibers. This characteristic pattern of changes in diffusion tensor eigenvalues has been observed previously in cases of Wallerian degeneration. Low-anisotropy regions corresponded to gray matter and gray/white interface regions. Since fiber tract orientations are not determined for regions of low anisotropy, this characteristic pattern of diffusion change is not detectable in these regions.Conclusion: Examination of diffusion tensor eigenvectors may provide insight into the changes observed in diffusion and a signature of Wallerian degeneration in the normal-appearing white matter of relapsing-remitting multiple sclerosis patients.