Opinion - The origin of the cancer stem cell: current controversies and new insights
Opinion - The origin of the cancer stem cell: current controversies and new insights
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DOI：
10.1038/nrc1740
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发表时间：
2005-11-01
影响因子：
78.5
通讯作者：
Terzis, AJA
中科院分区：
文献类型：
--
作者：
Bjerkvig, R;Tysnes, BB;Terzis, AJA
大多数肿瘤来源于单个细胞，该细胞转化为具有增殖能力并在体内形成肿瘤的致癌细胞（癌症干细胞）。然而，癌症干细胞的起源仍然是一个谜。有趣的是，在发育和组织修复过程中，不同来源的细胞之间的遗传和细胞质物质的融合是一个重要的生理过程。这种细胞融合和水平基因转移事件也与癌症的几个基本特征有关，并且在癌症干细胞的发展中可能是重要的。
Most tumours are derived from a single cell that is transformed into a cancer-initiating cell ( cancer stem cell) that has the capacity to proliferate and form tumours in vivo. However, the origin of the cancer stem cell remains elusive. Interestingly, during development and tissue repair the fusion of genetic and cytoplasmic material between cells of different origins is an important physiological process. Such cell fusion and horizontal gene-transfer events have also been linked to several fundamental features of cancer and could be important in the development of the cancer stem cell.