Infant feeding bottle design, growth and behaviour: results from a randomised trial.
Infant feeding bottle design, growth and behaviour: results from a randomised trial.
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DOI：
10.1186/1756-0500-5-150
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发表时间：
2012-03-16
影响因子：
1.8
通讯作者：
Lucas, A
中科院分区：
文献类型：
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作者：
Fewtrell, M S;Kennedy, K;Lucas, A
背景：防真空婴儿奶瓶的设计是否会影响婴儿的乳汁摄入量、生长或行为尚不清楚，并且是本次随机试验的主题。方法：受试者：63 名（36 名男性）健康、纯配方奶喂养的足月婴儿。干预：随机使用奶瓶 A（n = 31）、单向空气阀：飞利浦新安怡）与奶瓶 B（n = 32）、内部通风系统：布朗博士）。招募了 74 名母乳喂养的参考婴儿，如果随后引入奶瓶喂养，则随机分配 (n = 24) 至奶瓶 A (n = 11) 或 B (n = 13)。随机化：按性别和胎次分层；由独立临床试验单位基于计算机的电话随机化。地点：婴儿之家。主要结果测量：婴儿体重增加至 4 周。次要结果：(i) 牛奶摄入量 (ii) 2 周时测量的婴儿行为（经过验证的 3 天日记）； (iii) 感染风险； (iv) 引入混合喂养后继续母乳喂养。结果：主要结果分析数量：A 瓶 n = 29，B 瓶 n = 25。 主要结果：随机分组之间体重增加无显着差异（0-4 周 A 瓶 0.74 (SD 1.2) SDS 与 B 瓶 0.51 (0.39)，平均差 0.23 (95% CI -0.31 至0.77）。次要结果：使用 A 奶瓶的婴儿比使用 B 奶瓶的婴儿明显较少烦躁（平均 46 分钟/天，p < 0.05）。任何其他结果测量均无显着差异。母乳喂养参考组：母乳喂养和配方奶喂养的婴儿之间的主要或次要结果没有显着差异。随后随机使用奶瓶喂养的婴儿在 3 个月时母乳喂养的可能性没有显着差异。 A 或 B.结论：奶瓶设计可能对婴儿行为产生短期影响，值得进一步研究，对牛奶摄入量或生长没有显着影响；这些结果的可信度受到小样本量的限制，需要在更大的研究中进行确认。试验注册：Clinical Trials.gov NCT00325208。
BACKGROUND: Whether the design of an anti-vacuum infant feeding bottle influences infant milk intake, growth or behavior is unknown, and was the subject of this randomized trial.METHODS:SUBJECTS: 63 (36 male) healthy, exclusively formula-fed term infants.INTERVENTION: Randomisation to use Bottle A (n = 31), one-way air valve: Philips Avent) versus Bottle B (n = 32), internal venting system: Dr Browns). 74 breast-fed reference infants were recruited, with randomisation (n = 24) to bottle A (n = 11) or B (n = 13) if bottle-feeding was subsequently introduced. Randomisation: stratified by gender and parity; computer-based telephone randomisation by independent clinical trials unit.SETTING: Infant home.PRIMARY OUTCOME MEASURE: infant weight gain to 4 weeks.SECONDARY OUTCOMES: (i) milk intake (ii) infant behaviour measured at 2 weeks (validated 3-day diary); (iii) risk of infection; (iv) continuation of breastfeeding following introduction of mixed feeding.RESULTS: Number analysed for primary outcome: Bottle A n = 29, Bottle B n = 25.PRIMARY OUTCOME: There was no significant difference in weight gain between randomised groups (0-4 weeks Bottle A 0.74 (SD 1.2) SDS versus bottle B 0.51 (0.39), mean difference 0.23 (95% CI -0.31 to 0.77).SECONDARY OUTCOMES: Infants using bottle A had significantly less reported fussing (mean 46 versus 74 minutes/day, p < 0.05) than those using bottle B. There was no significant difference in any other outcome measure. Breast-fed reference group: There were no significant differences in primary or secondary outcomes between breast-fed and formula fed infants. The likelyhood of breastfeeding at 3 months was not significantly different in infants subsequently randomised to bottle A or B.CONCLUSION: Bottle design may have short-term effects on infant behaviour which merit further investigation. No significant effects were seen on milk intake or growth; confidence in these findings is limited by the small sample size and this needs confirmation in a larger study.TRIAL REGISTRATION: Clinical Trials.gov NCT00325208.