Replication of a genome-wide association study of panic disorder in a Japanese population
Replication of a genome-wide association study of panic disorder in a Japanese population
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DOI：
10.1038/jhg.2009.127
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发表时间：
2010-02-01
影响因子：
3.5
通讯作者：
Sasaki, Tsukasa
中科院分区：
文献类型：
--
作者：
Otowa, Takeshi;Tanii, Hisashi;Sasaki, Tsukasa
惊恐障碍（PD）是一种以反复发作和意外的惊恐发作为特征的焦虑障碍，随后出现担忧和恐惧回避。虽然已经进行了一些关联和连锁研究，没有基因被确定为易感基因座。我们之前使用500 K单核苷酸多态性（SNP）芯片对200名日本患者和相同数量的对照进行了PD的全基因组关联分析。在这项研究中，我们报告了使用DigTag2检测PD的复制分析。第二阶段样本包括558名日本患者和566名对照。在复制样品中测试了32个标记物。因此，在多重检验校正后，未发现显著相关性。然而，在名义等位基因P值处观察到差异
Panic disorder (PD) is an anxiety disorder characterized by recurrent and unexpected panic attacks, subsequent worry and phobic avoidance. Although a number of association and linkage studies have been conducted, no gene has been identified as a susceptibility locus. We previously conducted a genome-wide association analysis of PD in 200 Japanese patients and the same number of controls, using a 500 K single nucleotide polymorphisms (SNPs) chip. In this study, we report a replication analysis of PD using the DigTag2 assay. The second stage sample consisted of 558 Japanese patients and 566 controls. Thirty-two markers were tested in a replication sample. As a result, no significant association was found after correction for multiple testing. However, the difference was observed at the nominal allele P-value