Carbapenemases in Acinetobacter baumannii: Review of their dissemination in Latin America
Carbapenemases in Acinetobacter baumannii: Review of their dissemination in Latin America
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DOI：
10.1016/j.ram.2017.10.006
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发表时间：
2018-09-01
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影响因子：
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通讯作者：
Famiglietti, Angela
中科院分区：
文献类型：
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作者：
Rodríguez, Carlos Hernán;Nastro, Marcela;Famiglietti, Angela
革兰氏阴性菌产生碳青霉烯酶导致的碳青霉烯耐药性是全球医疗保健领域最具挑战性的问题之一。我们回顾了拉丁美洲国家碳青霉烯类耐药鲍曼不动杆菌分离株中碳青霉烯酶的流行病学和患病率。在该地区观察到对抗菌剂，特别是对碳青霉烯类的高耐药率。OXA-23是传播最广泛的D-碳青霉烯类酶;它存在于该区域的所有国家，通常与地方性克隆CC 113/CC 79、CC 104/CC 15、CC 110/ST 25和CC 109/CC 1相关。OXA-72和NDM-1的出现代表了一种新的发现，在不同的国家同时观察到，并且没有克隆相关性，其中一些国家彼此相距较远，而OXA-143仅存在于巴西。进一步的区域内合作研究将使大多数国家更好地了解这些问题，从而可以实施控制这些分离株传播的政策。(C)2017年阿根廷微生物学会。出版社：Elsevier Espana，S.L.U.
Carbapenem resistance in gram-negative bacteria by production of carbapenemases is one of the most challenging issues regarding healthcare worldwide. We review the epidemiology and prevalence of carbapenemases in carbapenem-resistant Acinetobacter baumannii isolates from Latin American countries. High resistance rates to antimicrobial agents, particularly to carbapenems, are observed in this region. OXA-23 is the most widely disseminated class D-carbapenemase; it is present in all the countries of the region and is frequently associated to endemic clones CC113/CC79, CC104/CC15, CC110/ST25 and CC109/CC1. The emergence of OXA-72 and NDM-1 represents a novel finding which is observed simultaneously and without clonal relatedness in different countries, some of which are distant from one another, whereas OXA-143 is only present in Brazil. Further collaborative intraregional studies would provide a better understanding of these issues in most of the countries and thus, policies to control the spread of these isolates could be implemented. (C) 2017 Asociacion Argentina de Microbiologia. Published by Elsevier Espana, S.L.U.