Design of Enzyme Inhibitors as Drugs
Design of Enzyme Inhibitors as Drugs
复制标题
酶抑制剂药物的设计
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
T. Steinmetzer
中科院分区：
文献类型：
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作者：
Anjana Patel;H. Smith;T. Steinmetzer
抑制剂设计的一般方法肾素血管素抑制剂系统酶内酰胺酶抑制剂脑啡肽酶抑制剂单胺氧化酶抑制剂多胺氧化酶抑制剂酶激活不可逆抑制剂治疗感兴趣的磷酸吡哆醛依赖性酶胆碱酯酶和酯酶抑制剂以及有机磷抑制酯酶抑制剂的再激活剂的新进展花生四烯酸代谢途径酶选择性抑制剂二氢叶酸还原酶抗菌磺胺类抑制剂新生嘧啶途径酶抑制剂嘌呤生物合成抑制剂Na+K+ atp酶抑制剂，甾体类生物合成抑制剂，参与细菌细胞壁合成的酶，抑制蛋白酶的发展，选择性抑制剂，钙调素依赖性磷酸二酯酶和腺苷酸环化酶抑制剂，碳酸酐酶抑制剂，抑制细胞内甲基转移和氨基丙基转移反应的底物，产物的类似物，以及一些其他靶酶的过渡态抑制剂，作为潜在的临床药物。索引。
Introduction to the use of enzyme inhibitors as drugs general approaches to the design of inhibitors inhibitors of the Renin-Angiotens in system enzymes lactamase inhibitors enkephalinase inhibitors as drugs monoamine oxidase inhibitors polyamine oxidase inhibitors new developments in enzyme activated irreversible inhibitors of pyridoxal phosphate-dependent enzymes of therapeutic interest cholinesterase and esterase inhibitors and reactivators of organophosphorus-inhibited esterases inhibitors of enzymes of the arachidonic acid metabolic pathways selective inhibitors of dihydrofolate reductases the antibacterial sulphonamides inhibitors of enzymes of the de novo pyrimidine pathway inhibitors of purine biosynthesis inhibitors of Na+, K+ ATpase inhibitors of steriod biosynthesis inhibitions of enzymes involved in bacterial cell wall synthesis inhibition of proteinases development of selective inhibitors of calmodulin-dependent phosphodiesterase and adenylate cyclase inhibitors of carbonic anhydrase inhibition of intracellular methyl transfer and aminopropyl transfer reactions by analogues of substrates, products, and transition states inhibitors of some other target enzymes as potential clinical agents. Index.