The ratio of plasma high-density lipoprotein cholesterol to total and low-density lipoprotein cholesterol: age-related changes and race and sex differences in selected North American populations. The Lipid Research Clinics Program Prevalence Study.
The ratio of plasma high-density lipoprotein cholesterol to total and low-density lipoprotein cholesterol: age-related changes and race and sex differences in selected North American populations. The Lipid Research Clinics Program Prevalence Study.
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血浆高密度脂蛋白胆固醇与总密度脂蛋白胆固醇和低密度脂蛋白胆固醇的比率：特定北美人群的年龄相关变化以及种族和性别差异。
DOI：
10.1161/01.cir.72.1.93
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发表时间：
1985
期刊：
影响因子：
37.8
通讯作者：
Tyroler,HA
中科院分区：
文献类型：
--
作者：
Green,MS;Heiss,G;Rifkind,BM;Cooper,GR;Williams,OD;Tyroler,HA
本文报告了6900名4岁以上白色和495名4岁以上黑人受检者血浆高密度脂蛋白胆固醇（HDL-C）与总胆固醇（TC）和HDL-C与低密度脂蛋白胆固醇（LDL-C）比值的分布。在脂质研究诊所（LRC）项目患病率研究的访视2调查期间获得测量值，并对应于LRC访视1调查期间筛选的60，502名参与者的15%随机样本。性别和白色女性性腺激素使用情况给出了女性特异性平均值、中位数和选定的平均值。在这些横断面数据中，明显的是白色男性受试者的HDL-C与TC的比值呈一致的年龄相关性下降，从5 - 9岁年龄组的平均值0.360下降到50 - 54岁年龄组的平均值0.211。此后，平均比率略有增加。在不使用性腺激素的白色女性中，与年龄相关的比率下降仅在35至39岁年龄组开始明显，从55至59岁年龄组从0.329下降到0.258。使用性腺激素的白色女性HDL-C/TC比值显示出非常小的年龄相关变化，平均值在0.300左右变化。受检的黑人人数较少，因此必须谨慎解释种族比较。对于每个性别，与年龄相关的趋势在黑人和白色研究参与者中相似。然而，在所有年龄组中，黑人男性以HDL-C形式携带的TC百分比高于白色男性。仅在20岁以下，黑人女性的TC在HDL-C中的百分比高于白色女性;在成人年龄范围内，未观察到明显差异。给出了脂质、脂蛋白和脂蛋白比率之间的Pearson相关系数。HDL-C/TC比值与HDL-C/LDL-C比值高度相关（所有组均大于0.92），前者可能是后者更方便测定的替代物。尽管HDL-C/TC比值传达的有关血脂模式的信息并不详尽，但它的优势在于将复杂的相关性总结为一个单一的数值近似值。
The distribution of the ratios of plasma high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) and of HDL-C to low-density lipoprotein cholesterol (LDL-C) are presented for 6900 white and 495 black examinees greater than 4 years old. Measurements were obtained during the visit 2 survey of the Lipid Research Clinics (LRC) Program Prevalence Study, and correspond to a 15% random sample of 60,502 participants screened during the LRC visit 1 survey. Age-specific means, medians, and selected percentiles are given by sex and by gonadal hormone use in white women. Apparent in these cross-sectional data was a consistent age-related decline in the ratio of HDL-C to TC for white male participants, from a mean of 0.360 in the age group 5 to 9 to a mean of 0.211 in the age group 50 to 54. Thereafter the mean ratio increased slightly. In white women not using gonadal hormones the age-related decline in the ratio was only evident starting at the age group 35 to 39, from which it declines from 0.329 to 0.258 in the age group 55 to 59. White women using gonadal hormones showed very minor age-related changes in the HDL-C/TC ratio, varying around a mean of 0.300. The number of blacks examined was low and thus the racial comparisons must be interpreted with caution. For each gender, age-related trends were similar in black and white study participants. Black men, however, had a higher percentage of TC carried as HDL-C than white men in all age groups examined. Black women had a higher percentage of TC in HDL-C than white women only below age 20; in the adult age range no appreciable differences were seen. Pearson correlation coefficients between the lipid, lipoprotein, and lipoprotein ratios are presented. The ratio HDL-C/TC correlated highly with the ratio HDL-C/LDL-C (greater than 0.92 for all groups) and the former may be a more conveniently determined surrogate for the latter. Although not exhaustive regarding the information it conveys about a lipid pattern, the ratio HDL-C/TC has the advantage of summarizing complex associations into a single numerical approximation.