Update on Biomarkers for the Detection of Endometriosis.
Update on Biomarkers for the Detection of Endometriosis.
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DOI：
10.1155/2015/130854
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发表时间：
2015
影响因子：
--
通讯作者：
Giudice L
中科院分区：
文献类型：
--
作者：
Fassbender A;Burney RO;O DF;D'Hooghe T;Giudice L
子宫内膜异位症的组织学特征是子宫内膜组织移位到子宫外的位置，包括盆腔腹膜、卵巢和肠道。子宫内膜异位症是不孕症和盆腔疼痛的重要原因，其个体和全球社会经济负担是显着的。腹腔镜检查仍然是诊断这种疾病的金标准。然而，手术的侵入性，加上缺乏该疾病的实验室生物标志物，导致从症状发作到确诊的平均潜伏期为7-11年。不幸的是，诊断的延迟可能会对疾病进展产生重大影响。对于子宫内膜异位症的非手术检测足够敏感和特异的生物标志物的发现，有望早期诊断和预防有害的后遗症，并代表了一个明确的研究优先事项。在这篇综述中，我们描述并讨论了血浆、尿液和子宫内膜中子宫内膜异位症生物标志物的现状。
Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7–11 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority. In this review, we describe and discuss the current status of biomarkers of endometriosis in plasma, urine, and endometrium.