Iron-Catalyzed Room Temperature Cross-Couplings of Bromophenols with Aryl Grignard Reagents
Iron-Catalyzed Room Temperature Cross-Couplings of Bromophenols with Aryl Grignard Reagents
复制标题
铁催化溴酚与芳基格氏试剂的室温交叉偶联
DOI：
10.1002/adsc.201900839
复制
发表时间：
2019
影响因子：
5.4
通讯作者：
Duan Xin Fang
中科院分区：
文献类型：
--
作者：
Xu Li Chen;Liu Kun Ming;Duan Xin Fang
本文报道了一种室温下铁催化的溴代苯酚与芳基格氏试剂的偶联反应，该反应具有底物范围广、官能团耐受性高的特点。首次将简单的Fe（acac）_3/PBu_3/Ti（OEt）_4催化剂用于溴代苯酚及其钠盐或钾盐的联芳基偶联反应，并能有效地抑制脱溴和醚化副反应.利用该方法合成了天然产物大蒜素联苯C、药物二氟尼柳及其乙酯等多种双酚类化合物。
Herein we report a room temperature Fe‐catalyzed coupling reaction of various bromophenols with aryl Grignard reagents, which exhibits a wide substrate scope and high functional group tolerance. For the first time, the combination of simple Fe(acac)3/PBu3/Ti(OEt)4has been used as an effective catalyst for the biaryl couplings of bromophenols or their Na or K salts with debromination and etherification side reactions being well suppressed. Various biphenols including natural product garcibiphenyl C as well as pharmaceutical diflunisal and its ethyl ester were facilely synthesized using the present protocol.