Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula
Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula
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DOI：
10.1016/j.earlhumdev.2006.11.003
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发表时间：
2007-05-01
影响因子：
2.5
通讯作者：
Hoffman, Dennis
中科院分区：
文献类型：
--
作者：
Birch, Eileen E.;Garfield, Sharon;Hoffman, Dennis
背景：虽然有大量关于婴儿配方奶粉中添加长链多不饱和脂肪酸对婴儿视觉和认知成熟的影响的数据，但来自随机试验的长期视觉和认知结果数据很少。目的：评价补充二十二碳六烯酸（DHA）和花生四烯酸（ARA）对4岁婴幼儿视力和认知能力的影响。方法：79名健康足月婴儿中有52名参加了一项单中心、双盲、随机临床试验，在4岁时进行了DHA和ARA补充婴儿配方奶粉的随访。此外，32名母乳喂养的婴儿被视为“黄金标准”。结果测量是视力和韦氏学前和初级智力量表-修订。结果：4岁时，对照配方奶粉组视力低于母乳喂养组；DHA和DHA+ ara补充组与母乳喂养组没有显著差异。对照组和dha补充组的语言智商得分低于母乳喂养组。结论：婴儿配方奶粉中添加DHA和ara可促进与母乳喂养婴儿相似的视力和智商成熟。2006爱思唯尔爱尔兰有限公司版权所有。
Background: While there is a large body of data on the effects of long-chain polyunsaturated fatty acid supplementation of infant formula on visual and cognitive maturation during infancy, longterm visual and cognitive outcome data from randomized trials are scarce. Aim: To evaluate docosahexaenoic acid (DHA) and arachidonic acid (ARA)-supplementation of infant formula on visual and cognitive outcomes at 4 years of age.Methods: Fifty-two of 79 healthy term infants who were enrolled in a single-center, double-blind, randomized clinical trial of DHA and ARA supplementation of infant formula were available for follow-up at 4 years of age. In addition, 32 breast-fed infants served as a "gold standard". Outcome measures were visual acuity and the Wechsler Preschool and Primary Scale of Intelligence - Revised. Results: At 4 years, the control formula group had poorer visual acuity than the breast-fed group; the DHA- and DHA+ARA-supplemented groups did not differ significantly from the breast-fed group. The control formula and DHA-supplemented groups had Verbal IQ scores poorer than the breast-fed group.Conclusion: DHA and ARA-supplementation of infant formula supports visual acuity and IQ maturation similar to that of breast-fed infants. (C) 2006 Elsevier Ireland Ltd. All rights reserved.