Azole resistance in neonatal intensive care units in Argentina
Azole resistance in neonatal intensive care units in Argentina
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DOI：
10.1179/joc.2005.17.3.347
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发表时间：
2005-06-01
影响因子：
1.8
通讯作者：
Gómez, V
中科院分区：
文献类型：
--
作者：
Giusiano, G;Mangiaterra, M;Gómez, V
本研究的目的是确定抗真菌药敏谱和检测耐药菌株的酵母菌种分离的新生儿在重症监护病房。研究了从25个血流培养物、20个静脉导管、23个耻骨上抽吸物和24个直肠拭子中分离的92个菌株。光滑念珠菌对氟康唑耐药。克柔念珠菌对氟康唑耐药，对伊曲康唑交叉耐药。2株白念珠菌对唑类药物耐药，1株对伊曲康唑耐药，另1株对氟康唑耐药，且伊曲康唑的最低抑菌浓度（MIC）较高。所有热带念珠菌对氟康唑敏感，但其中2株对伊曲康唑耐药。值得注意的是，在未接受过抗真菌治疗的新生儿中检测到耐药菌株。观察到的真菌感染流行病学的变化和检测到的抗真菌药物耐药性强调了定期监测以观察和评估它们的重要性。
The aim of this study was to determine the antifungal susceptibility profile and to detect resistant strains of yeast species isolated from neonates in Intensive Care Units. 92 strains isolated from 25 bloodstream cultures, 20 venous catheters, 23 suprapubic aspirations and 24 rectal swabs were studied. A Candida glabrata strain resistant to fluconazole was detected. Candida krusei appeared with its inherent resistance to fluconazole and showed cross-resistance to itraconazole. Two Candida albicans strains were resistant to azoles, one to itraconazole and the other to fluconazolle with a high minimum inhibitory concentration (MIC) for itraconazole. All Candida tropicalis strains were susceptible to fluconazole but two of them showed resistance to itraconazole. The detection of resistant strains in neonates whom had not received previous antifungal therapy is noteworthy. The variations in the epidemiology of fungal infections observed and the antifungal resistance detected emphasize the importance of performing a regular surveillance to observe and to assess them.