Antimicrobial/Antifouling Polycarbonate Coatings: Role of Block Copolymer Architecture
Antimicrobial/Antifouling Polycarbonate Coatings: Role of Block Copolymer Architecture
复制标题
DOI：
10.1021/ma5022488
复制
发表时间：
2015-02
期刊：
影响因子：
5.5
通讯作者：
Zhi Xiang Voo;Majad Khan;K. Narayanan;D. Seah;J. Hedrick;Yi Yan Yang
中科院分区：
文献类型：
--
作者：
Zhi Xiang Voo;Majad Khan;K. Narayanan;D. Seah;J. Hedrick;Yi Yan Yang
导管相关感染的高患病率每年在医院中占超过30亿美元，并且导管表面上的抗微生物聚合物涂层可以用作减轻感染的有吸引力的武器。合成了由三个关键组分组成的三嵌段聚碳酸酯聚合物，包括聚乙二醇（PEG），抗菌阳离子聚碳酸酯和拴系或粘合剂功能块。在这项研究中，块的拓扑结构或独特的块的位置是不同的，它们的功效作为抗菌剂和消毒剂的涂层表面上进行了研究。将各个块设计为具有相当的长度，随后在温和条件下通过共价键合将其接枝到预官能化的导管表面上。基于马来酰亚胺官能化碳酸酯的锚定/粘合功能部分位于聚合物嵌段的中心或末端，随后通过Michael addit连接到表面。
The high prevalence of catheter-associated infections accounts for more than 3 billion dollars annually in hospitals, and antimicrobial polymer coatings on catheter surface may serve as an attractive weapon to mitigate infections. Triblock polycarbonate polymers consisting of three critical components including antifouling poly(ethylene glycol) (PEG), antimicrobial cationic polycarbonate, and a tethering or adhesive functional block were synthesized. In this study, the block topology or placement of the distinctive blocks was varied and their efficacy as antimicrobial and antifouling agents investigated on coated surfaces. The individual blocks were designed to have comparable lengths that were subsequently grafted onto a prefunctionalized catheter surface through covalent bonding under mild conditions. The anchoring/adhesive functional moiety based on a maleimide functional carbonate was positioned at either the center or end of the polymer block and subsequently tethered to the surface via Michael addit...