Frequent, independent transfers of a catabolic gene from bacteria to contrasted filamentous eukaryotes
Frequent, independent transfers of a catabolic gene from bacteria to contrasted filamentous eukaryotes
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DOI：
10.1098/rspb.2014.0848
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发表时间：
2014-08-22
影响因子：
4.7
通讯作者：
Muller, Daniel
中科院分区：
文献类型：
--
作者：
Bruto, Maxime;Prigent-Combaret, Claire;Muller, Daniel
即使是遗传距离较远的原核生物也可以在它们之间交换基因，这些水平基因转移事件在适应和进化中发挥着核心作用。虽然长期以来人们认为这仅限于原核生物，但某些真核生物已经获得了细菌起源的基因。然而，真核生物中的基因获取在重要性上被认为远不如原核生物中的重要。在这里，我们描述了细菌分解代谢基因的复杂进化史，该基因已从不同的细菌门反复转移到原生藻菌和真菌。事实上，系统发育分析表明该基因在这些丝状真核生物中多次获得——65 种微型真核生物有多达 15 个不同的事件。此外，一旦转移，该基因就获得了内含子，并在大多数接受者的 mRNA 数据库中得到表达。我们的结果表明，真核细胞中原核基因的有效域间转移和随后的适应可以以前所未有的规模发生。
Even genetically distant prokaryotes can exchange genes between them, and these horizontal gene transfer events play a central role in adaptation and evolution. While this was long thought to be restricted to prokaryotes, certain eukaryotes have acquired genes of bacterial origin. However, gene acquisitions in eukaryotes are thought to be much less important in magnitude than in prokaryotes. Here, we describe the complex evolutionary history of a bacterial catabolic gene that has been transferred repeatedly from different bacterial phyla to stramenopiles and fungi. Indeed, phylogenomic analysis pointed to multiple acquisitions of the gene in these filamentous eukaryotes-as many as 15 different events for 65 microeukaryotes. Furthermore, once transferred, this gene acquired introns and was found expressed in mRNA databases for most recipients. Our results show that effective inter-domain transfers and subsequent adaptation of a prokaryotic gene in eukaryotic cells can happen at an unprecedented magnitude.