Modeling intercellular interactions in early Mycobacterium infection.
Modeling intercellular interactions in early Mycobacterium infection.
复制标题
模拟早期分枝杆菌感染中的细胞间相互作用。
DOI：
10.1007/s11538-006-9103-y
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发表时间：
2006
影响因子：
3.5
通讯作者：
Koster,Frederick
中科院分区：
文献类型：
--
作者：
Warrender,Christina;Forrest,Stephanie;Koster,Frederick
结核分枝杆菌(Mtb)感染的特点是病原体与宿主细胞相互作用的局部性、大致球形的病变。控制感染或疾病的发展取决于单个细胞的行为，而个体细胞的行为又取决于当地的分子环境和与邻近细胞的接触。建模可以帮助我们理解驱动该系统整体动力学的非线性相互作用。感染的早期事件特别重要，空间效应和固有的随机过程也是如此。我们使用CyCells模拟器描述了一个早期分枝杆菌感染的模型，该模拟器旨在捕捉这些影响。我们将该模型的CyCells模拟与对Mtb反应的个别分量的几个实验观察相关联。
Infection withMycobacterium tuberculosis(Mtb) is characterized by localized, roughly spherical lesions within which the pathogen interacts with host cells. Containment of the infection or progression of disease depends on the behavior of individual cells, which, in turn, depends on the local molecular environment and on contact with neighboring cells. Modeling can help us understand the nonlinear interactions that drive the overall dynamics in this system. Early events in infection are particularly important, as are spatial effects and inherently stochastic processes. We describe a model of earlyMycobacteriuminfection using the CyCells simulator, which was designed to capture these effects. We relate CyCells simulations of the model to several experimental observations of individual components of the response toMtb.