Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes
Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes
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DOI：
10.1016/s0161-6420(02)01564-6
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发表时间：
2003-01-01
期刊：
影响因子：
13.7
通讯作者：
Mattox, C
中科院分区：
文献类型：
--
作者：
Guedes, V;Schuman, JS;Mattox, C
目的：评价黄斑厚度与青光眼诊断相关的假说。设计：横断面研究。研究对象：367人（534只眼），其中109名正常受试者166只眼，58名青光眼疑似患者83只眼，132名早期青光眼患者196只眼，68名晚期青光眼患者89只眼。方法：采用光学相干断层扫描（OCT）测量黄斑和神经纤维层（NFL）厚度，分析两者之间的相关性及与青光眼的关系。我们使用了商用和原型OCT装置，并评估了在同一天对同一只眼睛进行的测量之间的对应关系。结果：与正常受试者和早期或晚期青光眼患者相比，原型和商用OCT设备的所有NFL参数均有统计学差异（P < 0.001）。在正常受试者和晚期青光眼之间，原型和商用OCT设备的内环、外环和平均黄斑厚度存在显著差异（P < 0.001）。外圈是唯一的黄斑参数，可以显著区分正常和早期青光眼的原型或商业OCT单元（P = 0.003, P = 0.008分别）。对比正常眼和晚期青光眼平均NFL厚度的接收操作特征（AROC）曲线下面积为1.00，这两种设备的原型和商用OCT设备在同一天进行了眼睛扫描。对比在两台机器上同一天扫描的正常和晚期青光眼的平均黄斑厚度，原型OCT设备的AROC为0.88，商用OCT的AROC为0.80。结论：OCT测量的黄斑和NFL厚度与青光眼的相关性均有统计学意义，尽管NFL厚度比黄斑厚度的相关性更强。使用原型和商用OCT装置的结果之间有很好的对应关系。用OCT测量黄斑和NFL厚度可能对青光眼的临床评估有用。(C) 2003年由美国眼科学会出版。
Purpose: To evaluate the hypothesis that macular thickness correlates with the diagnosis of glaucoma.Design: Cross-sectional study.Participants: We studied 367 subjects (534 eyes), including 166 eyes of 109 normal subjects, 83 eyes of 58 glaucoma suspects, 196 eyes of 132 early glaucoma patients, and 89 eyes of 68 advanced glaucoma patients.Methods: We used optical coherence tomography (OCT) to measure macular and nerve fiber layer (NFL) thickness and to analyze their correlation with each other and with glaucoma status. We used both the commercial and prototype OCT units and evaluated correspondence between measurements performed on the same eyes on the same days.Main Outcome Measure: Macular and NFL thickness as measured by OCT.Results: All NFL parameters both in prototype and commercial OCT units were statistically significantly different comparing normal subjects and either early or advanced glaucoma (P < 0.001). Inner ring, outer ring, and mean macular thickness both in prototype and commercial OCT devices were found to be significantly different between normal subjects and advanced glaucomatous eyes (P < 0.001). The outer ring was the only macular parameter that could significantly differentiate between normal and early glaucoma with either the prototype or commercial OCT unit (P = 0.003, P = 0.008, respectively). The area under the receiver operator characteristic (AROC) curves comparing mean NFL thickness between normal and advanced glaucomatous eyes was 1.00 for both the prototype and commercial OCT devices for eyes scanned on both machines on the same day. The AROC comparing mean macular thickness in normal and advanced glaucomatous eyes scanned on both machines on the same day was 0.88 for the prototype OCT device and 0.80 for the commercial OCT.Conclusions: Both macular and NFL thickness as measured by OCT showed statistically significant correlations with glaucoma, although NFL thickness showed a stronger association than macular thickness. There was good correspondence between findings using both the prototype and commercial OCT units. Macular and NFL thickness measurements made with OCT may have usefulness in the clinical assessment of glaucoma. (C) 2003 by the American Academy of Ophthalmology.