PASAT in Detecting Cognitive Impairment in Relapsing-Remitting MS
PASAT in Detecting Cognitive Impairment in Relapsing-Remitting MS
复制标题
PASAT 用于检测复发缓解型多发性硬化症的认知障碍
DOI：
10.1080/09084280701319938
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发表时间：
2007
影响因子：
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通讯作者：
L. Hokkanen
中科院分区：
文献类型：
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作者：
E. Rosti;P. Hämäläinen;K. Koivisto;L. Hokkanen
PASAT 作为多发性硬化症功能复合物的一部分，在多发性硬化症 (MS) 临床试验中用作唯一的认知测量方法。在本研究中，我们评估了复发缓解型多发性硬化症患者认知障碍的频率和特征。我们使用全面的神经心理学检查作为“金标准”，评估了 PASAT 在 MS 相关认知障碍中的敏感性和特异性，以及可能混淆 PASAT 表现的因素。使用 PASAT 和综合神经心理学检查对 45 名复发缓解型 MS 患者和 48 名健康对照进行了研究。 MS 患者中认知功能障碍的发生率为 42%。多发性硬化症的认知障碍本质上是异质的，但其特征尤其是信息处理能力下降和记忆缺陷。 PASAT 对患者认知障碍的敏感性为 74%，特异性为 65%。认知障碍的错误分类似乎与自我报告的紧张和算术能力差有关。尽管 PASAT 在检测是否存在认知障碍方面具有令人满意的灵敏度，但其特异性可能受到混杂因素的限制。
The PASAT, as a part of the Multiple Sclerosis Functional Composite, is used as a sole measure of cognition in multiple sclerosis (MS) clinical trials. In the present study, we evaluated the frequency and characteristics of cognitive impairment among relapsing-remitting MS patients. Using a comprehensive neuropsychological examination as the “golden standard,” we assessed PASAT's sensitivity and specificity in MS-related cognitive impairment as well as factors possibly confounding PASAT performance. Forty-five relapsing-remitting MS patients and 48 healthy controls were studied using PASAT and a comprehensive neuropsychological examination. The frequency of cognitive dysfunction among MS patients was 42%. Cognitive impairment in MS was heterogeneous in nature but characterized, especially, by reduced information-processing ability and memory deficits. PASAT's sensitivity for patients' cognitive impairment was 74% and specificity 65%. Misclassification of cognitive impairment seemed to be associated with self-reported nervousness and poor arithmetic skills. Although PASAT offers satisfactory sensitivity in detecting the presence of cognitive impairment, its specificity may be limited by confounding factors.
干扰素β-1a对复发性多发性硬化症的神经心理学影响。
影响因子：
11.2
作者：
Fischer,JS;Priore,RL;Jacobs,LD;Cookfair,DL;Rudick,RA;Herndon,RM;Richert,JR;Salazar,AM;Goodkin,DE;Granger,CV;Simon,JH;Grafman,JH;Lezak,MD;O'ReillyHovey,KM;Perkins,KK;Barilla-Clark,D;Schacter,M;Shucard,DW;
通讯作者：
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