Spatial extent of beta oscillatory activity in and between the subthalamic nucleus and substantia nigra pars reticulata of Parkinson's disease patients
Spatial extent of beta oscillatory activity in and between the subthalamic nucleus and substantia nigra pars reticulata of Parkinson's disease patients
复制标题
DOI：
10.1016/j.expneurol.2012.09.021
复制
发表时间：
2013-07-01
影响因子：
5.3
通讯作者：
Hutchison, William D.
中科院分区：
文献类型：
--
作者：
Alavi, Mahan;Dostrovsky, Jonathan O.;Hutchison, William D.
帕金森病(PD)伴随着丘脑底核(STN)大量的β带(11 Hz-30 Hz)神经元和局部场电位(LFP)振荡活动。先前的研究表明，在间隔类似于1毫米的部位，神经元放电和β频率的LFP之间存在显着的一致性，并且在给予左旋多巴后，β振荡的LFP活性和一致性的幅度大大降低。然而，这些数据是从彼此邻近的大型DBS接触电极或微电极对收集的，因此尚不清楚STN的所有区域是否都是同步的。目前也不知道黑质网状部(SNR)的嘴唇和神经元活动是否显示β活动，以及它是否与STN活动相一致。因此，这项研究的目的是通过系统地改变双微电极之间的距离来测量左旋多巴以外的PD患者STN中β相干活动的空间范围以及STN和SNR之间的一致性。共收集了20例接受DBS-STN植入手术的患者的170对静息录音。使用两个最初相距1 mm的微电极，轨迹通过STN并进入SNR。一旦微电极进入背侧STN，其中一个保持不动，而另一个进入SNR大约4-6 mm的距离。我们从STN/STN(n=111)，STN/SNR(n=42)和SNR/SNR(n=17)获得了成对的记录。我们证实了先前的报道，当电极从背部驱动到腹侧STN并进入SNR时，p功率逐渐衰减。此外，我们发现在STN的背腹范围内存在显著的β-LFP一致性。详细的分析表明，至少部分腹侧STN和SNRβ活动是局部产生的，而不是来自背侧STN的体积传导，从而表明β振荡使基底节的输入和输出核同步。(C)2012 Elsevier Inc.保留所有权利。
Parkinson's disease (PD) is accompanied by a significant amount of beta-band (11 Hz-30 Hz) neuronal and local field potential (LFP) oscillatory activity in the subthalamic nucleus (STN). Previous studies have shown significant coherence between neuronal firing and LFPs at beta frequencies at sites separated by similar to 1 mm and that the magnitude of beta oscillatory LFP activity and coherence are greatly reduced following levodopa administration. However, these data have been collected from large DBS contact electrodes or pairs of microelectrodes in proximity to each other and so it is not clear whether all regions of STN are synchronized. It is also not known whether the LIP and neuronal activity in the substantia nigra pars reticulata (SNr) shows beta activity and whether it is coherent with STN activity. Therefore, the aim of this study was to measure the spatial extent of beta coherent activity in the STN and coherence between STN and SNr in PD patients OFF levodopa by systematically varying the distance between the dual microelectrodes. A total of 170 pairs of recordings were collected from 20 patients at rest undergoing DBS-STN implantation surgery. Trajectories passed dorsoventrally through STN and into SNr using two microelectrodes initially similar to 1 mm apart. Once the microelectrodes entered the dorsal STN, one of the two was held stationary, while the other one was advanced into SNr over a distance of similar to 4-6 mm. Pairs of recordings were obtained from STN/STN (n = 111), STN/SNr (n = 42), and SNr/SNr (n = 17).We confirmed previous reports of a progressive attenuation in p power as electrodes were driven from dorsal to ventral STN and into SNr. Furthermore, we found significant beta-LFP coherence across the dorsoventral extent of STN. Detailed analysis suggested that at least some of the ventral STN and SNr beta activity was locally generated rather than arising from volume conduction from dorsal STN and thus suggests that beta oscillations synchronize both the input and output nuclei of the basal ganglia. (C) 2012 Elsevier Inc. All rights reserved.