Abnormally Altered Patterns of Whole Brain Functional Connectivity Network of Posterior Cingulate Cortex in Remitted Geriatric Depression: A Longitudinal Study
Abnormally Altered Patterns of Whole Brain Functional Connectivity Network of Posterior Cingulate Cortex in Remitted Geriatric Depression: A Longitudinal Study
复制标题
老年抑郁症缓解后后扣带皮层全脑功能连接网络的异常改变模式：一项纵向研究
DOI：
10.1111/cns.12250
复制
发表时间：
2014-08-01
影响因子：
5.5
通讯作者：
Zhang, Zhi-Jun
中科院分区：
文献类型：
--
作者：
Jiang, Wen-Hao;Yuan, Yong-Gui;Zhang, Zhi-Jun
目的：一项纵向研究探讨了缓解的老年抑郁症（RGD）患者的持续性认知损害及其与PCC功能连接网络的潜在相关性。方法：共招募了14例RGD患者和18例匹配的对照。所有受试者在基线和随访时均完成神经心理学测试和功能磁共振成像扫描。在PCC中放置一个球形感兴趣区域以计算功能连接，并进一步分析大脑区域的纵向变化与神经心理学数据之间的相关性。结果：在基线和随访时，RGD患者的认知能力明显下降。在RGD组内检测到功能连接的改变模式，显示与神经心理学测试的相关性。PCC与小脑后叶功能连接的纵向变化与听觉言语记忆测验-回忆的纵向变化相关（r = 0.550，P = 0.042）。PCC与右侧海马旁回功能连接的纵向变化与连线测验A相关（r = 0.631，P = 0.015）。PCC与边缘上R之间的功能连接纵向变化与简易精神状态检查相关（r =-0.630，P = 0.016）。结论：RGD患者表现出更差的认知功能，PCC功能连接网络的改变可能在这些认知下降中起作用。
Aims: A longitudinal study investigated the remitted geriatric depression (RGD) patients' persistent cognitive impairment and potential correlation with their PCC functional connectivity network. Methods: A total of 14 RGD patients and 18 matched controls were recruited. All subjects finished the neuropsychological tests and functional magnetic resonance imaging scan at baseline and follow-up. A spherical region of interest was placed in PCC to calculate the functional connectivity, and further analysis was employed to detect correlations between longitudinal changes in the brain regions and neuropsychological data. Results: There were significant cognitive declines in RGD patients at baseline and follow-up. Altered patterns of functional connectivity were detected within the RGD group showing correlations with neuropsychological tests. The longitudinal change in functional connectivity between PCC and cerebellum posterior lobe was correlated with longitudinal changes in auditory verbal memory test-recall (r = 0.550, P = 0.042). The longitudinal change in functional connectivity between PCC and right parahippocampal gyrus was correlated with Trail Making Test-A (r = 0.631, P = 0.015). The longitudinal change in functional connectivity between PCC and supramarginal_ R was correlated with Mini-Mental State Examination (r = -0.630, P = 0.016). Conclusions: RGD patients performed worse cognitive function, and altered PCC functional connectivity network might have a role in these cognitive declines.