A new 'biased coin design' for the sequential allocation of two treatments
A new 'biased coin design' for the sequential allocation of two treatments
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DOI：
10.1111/j.1467-9876.2004.00436.x
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发表时间：
2004-01-01
影响因子：
1.6
通讯作者：
Giovagnoli, A
中科院分区：
文献类型：
--
作者：
Antognini, AB;Giovagnoli, A
埃夫隆的有偏硬币设计是一种众所周知的随机化技术，有助于在比较治疗的连续临床试验中消除选择偏倚，同时保持实验的公平平衡。有偏硬币设计的扩展已经由几个研究者提出，他们主要关注他们设计的大样本性质。我们修改Efron的程序，通过引入一个可调偏硬币设计，这是比他更灵活。我们将其与其他现有的硬币设计进行比较;在平衡和缺乏可预测性方面，其在小样本中的表现在许多情况下似乎是一种改进。相对于其他顺序随机分配程序。
Efron's biased coin design is a well-known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the biased coin design have been proposed by several researchers who have focused mainly on the large sample properties of their designs. We modify Efron's procedure by introducing an adjustable biased coin design, which is more flexible than his. We compare it with other existing coin designs; in terms of balance and lack of predictability, its performance for small samples appears in many cases to be an improvement with. respect to the other sequential randomized allocation procedures.