De Novo Synthesis of 1,4-Dihydropyridines and Pyridines
De Novo Synthesis of 1,4-Dihydropyridines and Pyridines
复制标题
DOI：
10.1021/ja303002a
复制
发表时间：
2012-06-06
影响因子：
15
通讯作者：
Evano, Gwilherm
中科院分区：
文献类型：
--
作者：
Gati, Wafa;Rammah, Mohamed M.;Evano, Gwilherm
报道了一种基于锂化/异构化/分子内碳酸化顺序合成1,4-二氢吡啶和吡啶的高效通用方法。这个过程提供了一个有效的、发散的、直接的入口，以广泛的多取代二氢吡啶和吡啶，从容易获得的n -烯丙基酰胺开始。
An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.