Synthesis Route for the Self-Assembly of Submicrometer-Sized Colloidosomes with Tailorable Nanopores
Synthesis Route for the Self-Assembly of Submicrometer-Sized Colloidosomes with Tailorable Nanopores
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DOI：
10.1021/cm401610a
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发表时间：
2013-09-10
影响因子：
8.6
通讯作者：
Rezwan, Kurosch
中科院分区：
文献类型：
--
作者：
Bollhorst, Tobias;Grieb, Tim;Rezwan, Kurosch
我们提出了一种合成路线，在环境条件下和温和的pH值下制造亚微米尺寸的胶体体，具有可定制的纳米孔径和孔隙率。所述胶囊通过金属氧化物纳米颗粒在油包水乳液中的乳液液滴上的自组装形成。通过将油溶性表面活性剂吸附在与水介质中形成胶体的颗粒带相同符号电荷的乳状液滴上，合成了具有正负zeta电位的胶体。中空胶囊是固有刚性的，不需要进一步稳定。通过改变纳米颗粒的大小和形状，我们能够调整胶囊表面的孔径和孔径分布。具有窄尺寸范围的高球形均匀性的颗粒产生具有主要为六边形紧密堆积的表面结构和窄孔径的胶体体，而椭圆形和不均匀形状的颗粒产生没有表面秩序和不一致结构的胶体体。在亚微米尺度上合成胶体体并定制孔形状和直径是其作为生命科学领域中活性剂的通用封装和释放平台的应用的关键一步。
We present a synthesis route to fabricate submicrometer-sized colloidosomes at ambient conditions and mild pH with tailorable nanopore sizes and porosity. The capsules are formed via self-assembly of metal oxide nanoparticles on emulsion droplets in a water-in-oil emulsion. Through the adsorption of oil-soluble surfactants on emulsion droplets, which carry the same sign of charge as the colloidosome-forming particles in aqueous media, colloidosomes with positive and negative zeta potentials were synthesized. The hollow capsules are inherently rigid and necessitated no further stabilization. By varying the sizes and shapes of the nanoparticles, we were able to tailor the pore diameters and pore size distributions on the surface of the capsules. Particles of high spherical uniformity with narrow size range generated colloidosomes with a mainly hexagonal close packed surface structure and narrow pore size, while particles of elliptical and uneven shape created colloidosomes with no surface order and an inconsistent structure. Synthesizing colloidosomes on the submicrometer scale and tailoring the pore shapes and diameters is a crucial step toward their application as a versatile encapsulation and release platform of active agents in the field of life sciences.