Geographic clustering of residence in early life and subsequent risk of breast cancer (United States)
Geographic clustering of residence in early life and subsequent risk of breast cancer (United States)
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DOI：
10.1007/s10552-004-1675-y
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发表时间：
2004-11-01
影响因子：
2.3
通讯作者：
Freudenheim, JL
中科院分区：
文献类型：
--
作者：
Han, DW;Rogerson, PA;Freudenheim, JL
目的：本研究侧重于地理集群的乳腺癌居住在早期生活的基础上，并确定时空聚集的情况下，controls.Methods：数据来自WEB研究（西方纽约暴露和乳腺癌研究），一个以人口为基础的病例对照研究的事件，病理证实的乳腺癌（1996-2001年）在伊利和尼亚加拉县。对照组与年龄、种族和居住县的病例频率相匹配。研究中使用的所有病例和对照均提供了终生居住史。病例和对照组之间的k-函数差异被用来确定居住在早期life.Results的空间聚类模式：我们发现，在出生时和初潮的聚集居住的证据是强于第一次出生或其他时间段在成年后的生活。在出生和月经初潮时，绝经前病例的居住地比对照组更集中。我们还确定了在研究区域的大小和地理位置的出生和月经初潮集群，并发现增加乳腺癌的风险绝经前妇女的居住在集群内相比，那些生活在其他地方的时间birth.Conclusion：这项研究提供的证据表明，早期环境暴露可能与乳腺癌的风险，特别是绝经前妇女。
Objective: This study focused on geographic clustering of breast cancer based on residence in early life and identified spatio-temporal clustering of cases and controls.Methods: Data were drawn from the WEB study (Western New York Exposures and Breast Cancer Study), a population-based case-control study of incident, pathologically confirmed breast cancer (1996-2001) in Erie and Niagara counties. Controls were frequency-matched to cases on age, race, and county of residence. All cases and controls used in the study provided lifetime residential histories. The k-function difference between cases and controls was used to identify spatial clustering patterns of residence in early life.Results: We found that the evidence for clustered residences at birth and at menarche was stronger than that for first birth or other time periods in adult life. Residences for pre-menopausal cases were more clustered than for controls at the time of birth and menarche. We also identified the size and geographic location of birth and menarche clusters in the study area, and found increased breast cancer risk for pre-menopausal women whose residence was within the cluster compared to those living elsewhere at the time of birth.Conclusion: This study provides evidence that early environmental exposures may be related to breast cancer risk, especially for pre-menopausal women.