Leisure Time Spent Sitting in Relation to Total Mortality in a Prospective Cohort of US Adults
Leisure Time Spent Sitting in Relation to Total Mortality in a Prospective Cohort of US Adults
复制标题
DOI：
10.1093/aje/kwq155
复制
发表时间：
2010-08-15
影响因子：
5
通讯作者：
Thun, Michael J.
中科院分区：
文献类型：
--
作者：
Patel, Alpa V.;Bernstein, Leslie;Thun, Michael J.
肥胖流行的部分原因是体力活动减少。有证据表明，无论活动如何，减少坐着的时间可能会改善肥胖的代谢后果。美国癌症协会对美国成年人进行的一项大型前瞻性研究进行了分析，以检查坐着和身体活动所花费的闲暇时间与死亡率的关系。通过问卷调查，调查了 53,440 名男性和 69,776 名在入组时未患病的女性的坐姿和体力活动时间。作者在 14 年的随访期间发现，男性死亡人数为 11,307 人，女性死亡人数为 7,923 人。调整吸烟、体重指数和其他因素后，坐姿时间（>= 6 小时与 < 3 小时/天）与女性（相对风险 = 1.34，95% 置信区间 (CI)：1.25、1.44）和男性（相对风险 = 1.17，95% CI：1.11、1.24）的死亡率相关。与久坐时间最少、活动最多的人相比，久坐（>= 6 小时/天）和体力活动（< 24.5 代谢当量 (MET) 小时/周）的相对风险合计，女性为 1.94 (95% CI: 1.70, 2.20)，男性为 1.48 (95% CI: 1.33, 1.65)。心血管疾病死亡率的相关性最强。无论体力活动水平如何，坐着的时间与总死亡率独立相关。公共卫生信息应包括积极锻炼身体和减少久坐时间。
The obesity epidemic is attributed in part to reduced physical activity. Evidence supports that reducing time spent sitting, regardless of activity, may improve the metabolic consequences of obesity. Analyses were conducted in a large prospective study of US adults enrolled by the American Cancer Society to examine leisure time spent sitting and physical activity in relation to mortality. Time spent sitting and physical activity were queried by questionnaire on 53,440 men and 69,776 women who were disease free at enrollment. The authors identified 11,307 deaths in men and 7,923 deaths in women during the 14-year follow-up. After adjustment for smoking, body mass index, and other factors, time spent sitting (>= 6 vs. < 3 hours/day) was associated with mortality in both women (relative risk = 1.34, 95% confidence interval (CI): 1.25, 1.44) and men (relative risk = 1.17, 95% CI: 1.11, 1.24). Relative risks for sitting (>= 6 hours/day) and physical activity (< 24.5 metabolic equivalent (MET)-hours/week) combined were 1.94 (95% CI: 1.70, 2.20) for women and 1.48 (95% CI: 1.33, 1.65) for men, compared with those with the least time sitting and most activity. Associations were strongest for cardiovascular disease mortality. The time spent sitting was independently associated with total mortality, regardless of physical activity level. Public health messages should include both being physically active and reducing time spent sitting.