Mass trial of hypoallergenic rice (HRS-1) produced by enzymatic digestion in atopic dermatitis with suspected rice allergy. HRS-1 Research Group.
Mass trial of hypoallergenic rice (HRS-1) produced by enzymatic digestion in atopic dermatitis with suspected rice allergy. HRS-1 Research Group.
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通过酶消化产生的低过敏性大米（HRS-1）用于疑似大米过敏的特应性皮炎的大规模试验。
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发表时间：
1992
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通讯作者：
H. Suguro
中科院分区：
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作者：
Z. Ikezawa;T. Ikebe;H. Ogura;H. Odajima;F. Kurosaka;H. Komatu;K. Sase;C. Suga;M. Sugiuchi;H. Suguro
对44例疑有大米过敏的特应性皮炎（AD）患者进行了多中心研究，评价了由酶解原大米中的蛋白质组成而制得的低过敏性大米（HRS-1）的临床应用价值。受试者用HRS-1喂养至少4周，而不是从日常饮食中消除普通大米和小麦。总体皮肤病变的程度通过使用AD受累面积和严重程度指数（ADASI）表示。在第2周和第4周读数以及研究结束时观察到ADASI统计学显著性降低。在HRS-1治疗后的44名受试者中的5名中进行了普通大米的激发试验。5例患者术后即刻ADASI均明显增高。在最终评估中，77%的受试患者表现出“中度”至“显著”的改善，59%的患者在同时用于治疗的类固醇软膏的使用中“中度”至“显著”减少。最后，HRS-1在69%的受试者中被评价为"有用"或"非常有用"。
The clinical usefulness of a hypoallergenic rice (HRS-1) which was produced by enzymatic decomposition of the constituent proteins of original rice was evaluated in a multicentre study in 44 subjects with recalcitrant atopic dermatitis (AD), who were suspected of having rice allergy. The subjects were fed for at least 4 weeks with HRS-1 instead of eliminating both regular rice and wheat from their daily diet. The extent of overall skin lesions was expressed by using the AD affected area and severity index (ADASI). A statistically significant decrease in ADASI was observed at the 2nd and the 4th week readings and at the end of the study. A provocation test with regular rice was carried out in 5 of 44 subjects following the HRS-1 therapy. An obvious increase in ADASI was found in all of these 5 cases just after this procedure. On final evaluation, 77% of the patients tested showed 'moderate' to 'remarkable' improvement, and 59% of the patients a 'moderate' to 'remarkable' reduction in use of the steroid ointment concomitantly used for the treatment. Finally, HRS-1 was evaluated as 'useful' or 'very useful' in 69% of the subjects.