Injectable hydrogels for cartilage and bone tissue engineering.
Injectable hydrogels for cartilage and bone tissue engineering.
复制标题
用于软骨和骨组织工程的可注射水凝胶
DOI：
10.1038/boneres.2017.14
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发表时间：
2017
期刊：
影响因子：
12.7
通讯作者：
He N
中科院分区：
文献类型：
--
作者：
Liu M;Zeng X;Ma C;Yi H;Ali Z;Mou X;Li S;Deng Y;He N
组织工程已成为修复受损软骨和骨组织的一种有前途的策略。在用于组织工程应用的支架中，可注射水凝胶由于其高含水量、与天然细胞外基质（ECM）的相似性、用于细胞移植和增殖的多孔框架、微创特性以及匹配不规则缺损的能力而被证明在软骨和骨组织工程中用作三维细胞培养支架方面具有巨大的潜力。本文综述了近年来用于软骨和骨组织工程的新型可注射水凝胶材料的选择和制备方法。此外，还对软骨和骨细胞外基质的生物学特性进行了综述。最后，可注射水凝胶在软骨和骨组织工程的未来前景进行了讨论。
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.