Long-term Outcomes of a Dose-reduction Trial to Decrease Late Gastrointestinal Toxicity in Patients with Prostate Cancer Receiving Soft Tissue-matched Image-guided Intensity-modulated Radiotherapy
Long-term Outcomes of a Dose-reduction Trial to Decrease Late Gastrointestinal Toxicity in Patients with Prostate Cancer Receiving Soft Tissue-matched Image-guided Intensity-modulated Radiotherapy
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DOI：
10.21873/anticanres.12234
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发表时间：
2018-01-01
影响因子：
2
通讯作者：
Yoshida, Ken
中科院分区：
文献类型：
--
作者：
Sasaki, Naomi;Yamazaki, Hideya;Yoshida, Ken
背景/目的：在我们最初的2.2Gy/次前列腺癌治疗方案中，接受图像引导调强放射治疗(IG-IMRT)的前列腺癌患者发生了意想不到的高胃肠道(GI)毒性；因此，我们使用改进的计划靶体积(PTV)等高线进行了剂量减少试验，从2.2Gy/次降至2Gy/次。患者和方法：我们比较了130例接受2.2Gy/次治疗的患者(A组)和144例接受改良PTV(不包括直肠体积)的患者(B组)，中位随访时间为62个月。处方剂量为72.6~74.8Gy33~34次(A组)，72~74Gy36~37次(B组)。结果：B组患者直肠和膀胱V10-V70降低，照射剂量最大。他们年级的累积发病率
Background/Aim: We experienced an unexpected high incidence of gastrointestinal (GI) toxicity in patients undergoing image-guided intensity-modulated radiotherapy (IG-IMRT) using helical tomotherapy in our initial 2.2 Gy/fraction schedule for prostate cancer; hence, a dose-reduction trial from 2.2 Gy to 2 Gy/fraction was conducted using modified planning target volume (PTV) contouring. Patients and Methods: We compared 130 patients treated using 2.2 Gy/fraction (Group A) and 144 treated using the 2 Gy/fraction (Group B) with modified PTV (excluding rectal volume) with a median follow-up period of 62 months. Prescribed dose was 72.6-74.8 Gy in 33-34 fractions (Group A) and 72-74 Gy in 36-37 fractions (Group B). Results: Patients in Group B had a reduced rectal and bladder V10-V70 and were irradiated at the maximal dose. Their cumulative incidence of grade