A preliminary study of angiogenesis in paediatric glioblastoma multiforme and its correlation with survival
A preliminary study of angiogenesis in paediatric glioblastoma multiforme and its correlation with survival
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DOI：
10.1007/s003810100489
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发表时间：
2001-10-01
影响因子：
1.4
通讯作者：
Tomasello, F
中科院分区：
文献类型：
--
作者：
Germanò, A;Caffo, M;Tomasello, F
目标：将现代见解引入神经胶质瘤的发生以改善患者的治疗效果是一个明显的挑战。神经肿瘤学、神经放射学、神经病理学和神经外科研究提供的见解可能为儿科 GBM 的治疗提供显着优势。本研究的目的是评估血管生成作为儿童多形性胶质母细胞瘤 (GBM) 生存的潜在指标。方法：采用多种标准评估 6 例儿童 GBM 的血管生成情况，包括术前 CT 扫描对比增强、组织学血管增生（VH）和内皮增殖（EP）以及免疫组织化学腱蛋白-C（TN-C）表达。对于每个研究参数，我们采用半定量尺度，范围从未检测到（零）到标记（+3）。我们评估了每个病例中血管生成对生存的影响。结论：在这项初步研究中，血管生成提供了与生存相关的信息，尽管患者数量有限。随着我们对脑肿瘤的分子生物学有了更好的了解，随着大量的基因改变和生长因子的出现，新的治疗方法可能会出现，这可能会带来治愈的希望。
Objects: There is a distinct challenge in bringing modern insights into glial tumour genesis to bear on improved outcomes for patients. Insights provided by neuroncological, neuroradiological, neuropathological, and neurosurgical investigations may offer significant advantages in the management of paediatric GBM. The goal of this study was to evaluate angiogenesis as a potential indicator of survival in paediatric glioblastoma multiforme (GBM). Methods: Angiogenesis was evaluated in six cases of paediatric GBM with multiple criteria, including contrast enhancement on preoperative CT scan, histological vascular hyperplasia (VH) and endothelial proliferation (EP) and immunohistochemical tenascin-C (TN-C) expression. We employed a semi-quantitative scale, ranging from not detected (zero) to marked (+3), for each investigational parameter. We evaluated the influence of angiogenesis on survival in each case. Conclusions: In this preliminary study, angiogenesis provided information that correlated with survival, albeit in a limited number of patients. As we gain better understanding of the molecular biology of brain tumours, with the multitude of genetic alterations and growth factors new therapeutic approaches may emerge, which may hold the promise for cure.