Hydride-based silica stationary phases for HPLC: fundamental properties and applications.
Hydride-based silica stationary phases for HPLC: fundamental properties and applications.
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用于 HPLC 的氢化物二氧化硅固定相：基本特性和应用。
DOI：
10.1002/jssc.200500201
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发表时间：
2005
影响因子：
3.1
通讯作者：
Matyska,MariaT
中科院分区：
文献类型：
--
作者：
Pesek,JosephJ;Matyska,MariaT
氢化二氧化硅是 HPLC 色谱支撑材料的最新发展，其中氢化物基团取代了表面 95% 的硅烷醇。这种转化改变了材料的许多基本特性以及键合固定相，这是氢化物表面进一步化学改性的结果。回顾了制备二氧化硅氢化物和后续键合相的一般方法。将二氧化硅表面的性质与在大多数商业 HPLC 固定相的制备中获得的标准材料的性质进行比较。描述了氢化物基相的一些独特的色谱性质以及一些一般应用领域，在这些领域中这些键合材料可以优先使用或具有典型固定相所没有的优点。
Silica hydride is a recent development in chromatographic support materials for HPLC where hydride groups replace 95% of the silanols on the surface. This conversion changes many of the fundamental properties of the material as well as the bonded stationary phases that are the result of further chemical modification of the hydride surface. The general approach for fabricating the silica hydride and subsequent bonded phases is reviewed. Properties of the silica hydride surface are compared to those of the standard material obtained in the preparation of most commercial HPLC stationary phases. Some unique chromatographic properties of hydride‐based phases are described as well as some general application areas where these bonded materials may be used in preference to or have advantages not available from typical stationary phases.