Projections from orbitofrontal cortex to anterior piriform cortex in the rat suggest a role in olfactory information processing
Projections from orbitofrontal cortex to anterior piriform cortex in the rat suggest a role in olfactory information processing
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DOI：
10.1002/cne.20595
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发表时间：
2005-07-25
影响因子：
2.5
通讯作者：
Illig, KR
中科院分区：
文献类型：
--
作者：
Illig, KR
眶额皮质（OFC）是一个高级的多模态感觉皮质。在大鼠的电生理和行为研究的证据表明，眶额皮层在调节嗅觉引导行为中起作用，和一个重要的投射到眶额皮层来自梨状皮质，传统的初级嗅觉皮层。为了辨别OFC如何与初级嗅觉结构相互作用，将顺行示踪剂Phaseolus vulgaris leucoagglutinin注射到成年雄性大鼠的眶额皮质区。在注射同侧的梨状皮质和嗅球中发现标记纤维。值得注意的是，到梨状皮质的投射主要来自腹外侧眶皮质，并且不均匀;吻侧，到前梨状皮质（APC）的腹侧部分的投射是实质性的，而背侧A-PC几乎没有标记纤维。标记的纤维被发现在背侧和腹侧的部分在更尾部的区域的APC。大多数标记的纤维被发现在层III中，虽然观察到大量的纤维在层Ib和II。注射到眶额区后，在梨状皮质后部也观察到标记纤维。结合以往的研究结果，我们认为梨状皮质包括多个分区，它们可能在嗅觉信息处理中执行独立的、并行的功能。此外，这些结果表明，OFC，除了其假定的作用，在编码信息的意义的嗅觉刺激，可能发挥作用，在梨状皮质神经元的气味反应特性的调制。(c)2005年Wiley-Liss，Inc.
The orbitofrontal cortex (OFC) has been characterized as a higher-order, multimodal sensory cortex. Evidence from electrophysiological and behavioral studies in the rat has suggested that OFC plays a role in modulating olfactory guided behavior, and a significant projection to OFC arises from piriform cortex, the traditional primary olfactory cortex. To discern how OFC interacts with primary olfactory structures, the anterograde tracer Phaseolus vulgaris leucoagglutinin was injected into orbitofrontal cortical areas in adult male rats. Labeled fibers were found in the piriform cortex and olfactory bulb on the side ipsilateral to the injection. Notably, the projection to piriform cortex was predominantly from ventrolateral orbital cortex, and was not uniform; rostrally, the projection to the ventral portion of the anterior piriform cortex (APC) was substantial, while the dorsal A-PC was virtually free of labeled fibers. Labeled fibers were found in both the dorsal and ventral portions in more caudal regions of APC. Most labeled fibers were found in layer III, although a substantial number of fibers were observed in layers Ib and II. Labeled fibers in posterior piriform cortex also were seen after injection into orbitofrontal areas. Taken together with previous reports, these findings suggest that piriform cortex includes multiple subdivisions, which may perform separate, parallel functions in olfactory information processing. Further, these results suggest that the OFC, in addition to its putative role in encoding information about the significance of olfactory stimuli, may play a role in modulating odor response properties of neurons in piriform cortex. (c) 2005 Wiley-Liss, Inc.