Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation
Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation
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DOI：
10.1186/s13104-019-4855-2
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发表时间：
2019-12-18
影响因子：
1.8
通讯作者：
Bach, Ronald R.
中科院分区：
文献类型：
--
作者：
Butterick, Tammy A.;Trembley, Janeen H.;Bach, Ronald R.
海湾战争疾病是一种慢性多症状疾病，严重影响了1990-1991年海湾战争中许多退伍军人的健康和福祉。这种疾病的症状包括疼痛、疲劳、情绪和记忆障碍、胃肠道问题、肺部疾病和皮疹。在我们之前的生物标志物研究中，我们发现了海湾战争疾病相关的促炎性血液生物标志物。因此，我们假设慢性炎症导致了这种疾病的症状。测试慢性炎症假说是本study.ResultsThe生物标志物指纹的海湾战争疾病的目的是最终产品的促炎细胞因子信号级联。特别是，所观察到的C反应蛋白的增加预测了白细胞介素6的相应增加，白细胞介素6是刺激肝细胞产生C反应蛋白的细胞因子。因此，在这项研究中，我们测量了海湾战争退伍军人血浆样本中潜在的上游细胞因子信号。正如预测的那样，观察到白细胞介素6和C反应蛋白之间呈正相关。
ObjectiveGulf War Illness is a chronic multisymptom disorder severely impacting the health and well-being of many Veterans of the 1990-1991 Gulf War. Symptoms that define the disease include pain, fatigue, mood and memory impairments, gastrointestinal problems, lung disorders, and skin rashes. In our previous biomarker study, we discovered Gulf War Illness-associated proinflammatory blood biomarkers. Therefore, we hypothesized that chronic inflammation causes the symptoms that define this disorder. Testing the chronic inflammation hypothesis is the objective of this study.ResultsThe biomarker fingerprint of Gulf War Illness is the end-product of a cascade of proinflammatory cytokine signals. In particular, the observed increase in C-reactive protein predicts a corresponding increase in interleukin 6, the cytokine that stimulates hepatocytes to produce C-reactive protein. Therefore, in this study we measured potential upstream cytokine signals in plasma samples from Gulf War Veterans. As predicted, a positive correlation between interleukin 6 and C-reactive protein was observed.