Structural organization of the kinetochore-microtubule interface.

Structural organization of the kinetochore-microtubule interface.
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DOI:
10.1016/j.ceb.2011.11.003
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发表时间:
2012-02
影响因子:
7.5
通讯作者:
Musacchio, Andrea
Musacchio, Andrea
中科院分区:
生物学2区
文献类型:
--
作者:
DeLuca, Jennifer G.;Musacchio, Andrea

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Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites of centromeric heterochromatin, is responsible for generating and regulating these essential attachments. Over the last several years, concerted experimental efforts have brought the structural view of the kinetochore-microtubule interface more clearly into focus. Here, we review important recent advancements and discuss several unresolved questions regarding how kinetochores dynamically bridge mitotic chromosomes to spindle microtubules.
动力学 - 微管附着依赖于Hec1的无序N末端尾部结构域。
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