Is hormone replacement therapy a risk factor for low back pain among postmenopausal women?
Is hormone replacement therapy a risk factor for low back pain among postmenopausal women?
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DOI：
10.1097/00007632-199804010-00014
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发表时间：
1998-04-01
期刊：
影响因子：
3
通讯作者：
Hammar, ML
中科院分区：
文献类型：
--
作者：
Brynhildsen, JO;Björs, E;Hammar, ML
研究设计：两个年龄组的横断面研究。评估绝经后接受激素替代治疗的妇女是否比未接受这种治疗的妇女有更高的背部问题患病率。背痛是一种常见的医疗问题：在整个生命中，尤其是在怀孕期间。激素因素已被认为是一个可能的贡献者。1995年初，向居住在瑞典林雪平的所有1 324名55岁和56岁的妇女发送了一份经过验证的邮寄调查表。该问卷包括有关当前激素替代治疗、既往和当前背部问题、背部问题的医疗护理、产次、运动和吸烟习惯以及职业的问题。结果。84.7%的妇女交回了问卷。有一个显着的，虽然弱，目前使用激素替代治疗和腰痛之间的正相关。根据多元logistic回归分析，怀孕期间的背部问题是当前背痛的一个强有力的危险因素，而目前吸烟和定期体育锻炼都不是危险因素。吸烟和从事举重等职业的相互作用对背痛有显著影响。接受激素替代治疗的女性当前背痛的患病率略高于非使用者（分别为48%和42%，P < 0.05），但显着更高，这无法用职业、吸烟习惯或当前身体活动的差异来解释。虽然激素替代疗法和背部问题之间的联系很弱，可能临床意义不大，但据推测可能与激素对关节和韧带的影响有关。
Study Design, Cross-sectional study with two age cohorts.Objective. To assess whether women receiving hormone replacement therapy after menopause have a higher prevalence of back problems than women who do not receive such treatment.Background. Back pain is a common medical problem: throughout life and especially during pregnancy. Hormonal factors have been proposed as a possible contributor.Patients and Methods. A validated postal questionnaire was sent in early 1995 to all 1324 women of 55 years and 56 years of age residing in Linkoping, Sweden. This questionnaire included questions about current rent hormone replacement treatment, previous and current back problems, medical care for back problems, parity, exercise and smoking habits, and occupation.Results. The questionnaire was returned by 84.7% of the women. There was a significant, albeit weak, positive association between current use of hormone replacement treatment and low back pain. Previous back problems during pregnancy was a strong risk factor for current back pain, whereas neither current smoking nor regular physical exercise was a risk factor according to multiple logistic regression analysis. The interaction of smoking and an occupation involving heavy lifting significantly affected back pain.Conclusions. Women receiving hormone replacement treatment had a slightly, but significantly, higher prevalence of current back pain than nonusers (48% vs. 42%, respectively, P < 0.05), which could not be explained by differences in occupation, smoking habits, or current physical activity. Although the association be-tween hormone replacement therapy and back problems is weak and probably of minor clinical importance, it is speculated that hormonal effects on joints and ligaments may be involved.