Synthesis of functionalized resorcinols by rhodium-catalyzed [5+1] cycloaddition reaction of 3-acyloxy-1,4-enynes with CO
Synthesis of functionalized resorcinols by rhodium-catalyzed [5+1] cycloaddition reaction of 3-acyloxy-1,4-enynes with CO
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DOI：
10.1039/c0cc00747a
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Malacria, Max
中科院分区：
文献类型：
--
作者：
Brancour, Celia;Fukuyama, Takahide;Malacria, Max
以Rh配合物为催化剂，建立了一种新的[5+1]型羰基化环加成反应。该反应可将容易得到的3-酰基-1,4-炔和一氧化碳转化为多种功能化间苯二酚，收率高。在目前的[5+1]型环加成反应中，提出了一种rh催化的3-酰基-1,4-炔环羰基化并伴有1,2-酰基移位的机理。
A novel [5+1] type carbonylative cycloaddition reaction has been developed using a Rh complex as catalyst. This reaction can convert readily available 3-acyloxy-1,4-enynes and CO to a wide range of functionalized resorcinols in good yields. A mechanism involving Rh-catalyzed cyclocarbonylation of 3-acyloxy-1,4-enynes accompanied by a 1,2-acyloxy shift is proposed for the present [5+1] type cycloaddition reaction.