Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration
Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration
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DOI：
10.1136/gut.40.2.204
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发表时间：
1997-02-01
期刊：
影响因子：
24.5
通讯作者：
Hawkey, CJ
中科院分区：
文献类型：
--
作者：
Hull, MA;Knifton, A;Hawkey, CJ
背景：酸稳定碱性成纤维细胞生长因子（bFGF）促进大鼠胃溃疡血管生成和愈合，并减少随后非甾体抗炎药（NSAID）诱导的复发。目的：在一项双盲、安慰剂对照、三向交叉研究中检验bFGF是否能促进胃溃疡人类模型的发生并减少随后的复发。实验对象：12名健康志愿者。方法：受试者服用阿司匹林900 mg，每日2次（第1-3天），同时服用bFGF 0.1 mg，每日2次或西咪替丁400 mg， 2次吲哚美辛50 mg，每日3次（第15-21天），在每个治疗期的第1、4、8、15、22天进行内镜检查。第1天取8个胃窦活检标本，在随后的内窥镜检查中统计未愈合的活检引起的小溃疡和非甾体抗炎药引起的糜烂的数量。结果：与安慰剂组相比，基础FGF和西咪替丁对阿司匹林和吲哚美辛诱导的十二指肠（而非胃）损伤有保护作用，仅安慰剂组在吲哚美辛治疗后活检引起的小型溃疡复发显著(0（0-0）前vs（0-4.5）后；p > 0.05)。1名志愿者血清中检测到TGP-580。结论：在这种胃溃疡模型中，bFGF（和西咪替丁）的愈合与非甾体抗炎药诱导的溃疡替代减少有关。
Background-Acid stable basic fibroblast growth factor (bFGF) promotes angiogenesis and healing of gastric ulcers in rats and reduces subsequent non-steroidal anti-inflammatory drug (NSAID) induced relapse.Aims-To test in a double blind, placebo controlled, three way crossover study whether bFGF promotes headline and reduces subsequent relapse in a human model of gastric ulceration.Subjects-Twelve healthy volunteers.Methods-Subjects took aspirin 900 mg twice daily (days 1-3) with bFGF 0.1 mg twice daily or cimetidine 400 mg twice indomethacin 50 mg thrice daily (days 15-21), Endoscopy was performed on days 1, 4, 8, 15, and 22 during each treatment period. Eight antral biopsy specimens were taken on day 1 and the number of unhealed biopsy induced mini-ulcers and NSAID induced erosions counted during subsequent endoscopies.Results-Basic FGF and cimetidine were protective against aspirin and indomethacin induced duodenal (but not gastric) injury compared with placebo, There was significant relapse of biopsy induced mini-ulcers after indomethacin only in the placebo group (0 (0-0) before v 1 (0-4.5) after; p>0.05). TGP-580 was detected in serum of one volunteer.Conclusions-Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer replapse in this model of gastric ulceration.