Hippocampal evoked potentials in novel environments: a behavioral clamping method.
Hippocampal evoked potentials in novel environments: a behavioral clamping method.
复制标题
海马在新环境中诱发电位：一种行为钳制方法。
DOI：
10.1016/j.bbr.2006.04.016
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发表时间：
2006
影响因子：
2.7
通讯作者：
Sutherland,RobertJ
中科院分区：
文献类型：
--
作者：
Wu,Ying;Sutherland,RobertJ
海马体参与了新奇事物的检测，对于某些形式的学习环境事件和关系至关重要。海马突触可塑性的一种形式，长时程增强（LTP）的细胞和分子机制被认为与学习的神经机制明显重叠。在这项研究中，海马突触效能的变化进行了测量清醒，自由行为的大鼠在探索新的环境。由于海马生理学是由正在进行的行为，诱发电位收集在1型与2型行为分别进行了评估。在探索诱导的变化之前的LTP诱导在穿孔路径齿状突触的影响进行了评价。结果表明，探索引起的群体尖峰幅度的增加，而兴奋性突触后电位的变化在1型行为，持续时间超过5min。海马LTP的诱导阻断了探索引起的变化。这种变化不太可能是由于新奇引起的GABA能抑制减少。
The hippocampus is involved in the detection of novelty and is essential for certain forms of learning about environmental events and relationships. The cellular and molecular mechanisms of one form of hippocampal synaptic plasticity, long-term potentiation (LTP), are thought to overlap significantly with the neural mechanisms of learning. In this study changes in hippocampal synaptic efficacy were measured in awake, freely behaving rats during exploration of novel environments. Because hippocampal physiology is modulated by on-going behavior, evoked potentials collected during Type 1 versus Type 2 behavior were evaluated separately. The effect of prior LTP induction at perforant path-dentate synapses on exploration-induced changes was evaluated. The results show that exploration causes an increase in population spike amplitude with no change in excitatory postsynaptic potential during Type 1 behavior that lasts longer than 5min. Prior induction of hippocampal LTP occludes the change induced by exploration. This change is not likely to be due to a reduction of GABAergic inhibition induced by novelty.