Cardiovascular and renal responses to stress in borderline hypertensive rat.
Cardiovascular and renal responses to stress in borderline hypertensive rat.
复制标题
临界高血压大鼠的心血管和肾脏对应激的反应。
DOI：
10.1152/ajpregu.1988.255.3.r431
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Lawler,JE
中科院分区：
文献类型：
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作者：
Sanders,BJ;Cox,RH;Lawler,JE
将Wistar-Kyoto（WKY）和临界高血压大鼠（BHR）暴露于正常或高氯化钠（NaCl）饮食8周。心血管和肾脏的数据收集动脉和膀胱导管，分别在清醒的动物在控制和压力（厌恶经典条件反射）会议。结果表明，与正常饮食的BHR相比，高NaCl饮食的BHR对应激的血压没有增加。与正常NaCl对照组相比，高NaCl饮食减少了WKY应激期间血压恢复至基线。此外，与对照组相比，高氯化钠饮食和应激在BHR中相互作用，减少了应激期间的钠排泄和肾血浆流量（3.8与4.8 μ eq.min-1.100 g体重-1; 3.6与4.0 ml.min-1。100 g体重-1）。最后，增加饮食中的NaCl减弱了WKY对应激的去甲肾上腺素反应，但在BHR中没有（263对767 pg/ml）。这些数据表明，遗传和环境因素的相互作用是高血压发展的重要变量。
Wistar-Kyoto (WKY) and borderline hypertensive rats (BHR) were exposed to either a normal or high-sodium chloride (NaCl) diet for 8 wk. Cardiovascular and renal data were collected from arterial and bladder catheters, respectively, in conscious animals during control and stress (aversive classical conditioning) sessions. Results indicated that BHR on a high-NaCl diet exhibited no increase in blood pressure in response to stress compared with BHR on a normal diet. A high-NaCl diet diminished the recovery of blood pressure to base line during stress in WKY compared with normal NaCl controls. Also, a high-NaCl diet and stress interacted in the BHR to decrease sodium excretion and renal plasma flow during stress compared with the control session (3.8 vs. 4.8 mueq.min-1.100 g body wt-1; 3.6 vs. 4.0 ml.min-1. 100 g body wt-1, respectively). Finally, increased dietary NaCl blunted the norepinephrine response to stress in WKY but not in BHR (263 vs. 767 pg/ml). These data suggest that the interaction of genetic and environmental factors are important variables for the development of hypertension.