The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate.
The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate.
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DOI：
10.1242/bio.058761
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发表时间：
2021-07-15
期刊：
影响因子：
2.4
通讯作者：
Sokol SY
中科院分区：
文献类型：
--
作者：
Mancini P;Ossipova O;Sokol SY
Coordinated polarization of cells in the tissue plane, known as planar cell polarity (PCP), is associated with a signaling pathway critical for the control of morphogenetic processes. Although the segregation of PCP components to opposite cell borders is believed to play a critical role in this pathway, whether PCP derives from egg polarity or preexistent long-range gradient, or forms in response to a localized cue, remains a challenging question. Here we investigate the Xenopus neural plate, a tissue that has been previously shown to exhibit PCP. By imaging Vangl2 and Prickle3, we show that PCP is progressively acquired in the neural plate and requires a signal from the posterior region of the embryo. Tissue transplantations indicated that PCP is triggered in the neural plate by a planar cue from the dorsal blastopore lip. The PCP cue did not depend on the orientation of the graft and was distinct from neural inducers. These observations suggest that neuroectodermal PCP is not instructed by a preexisting molecular gradient but induced by a signal from the dorsal blastopore lip. Summary: The blastopore lip contains a cue that induces the progressive establishment of planar polarity in the neural plate in the posterior to anterior direction.
