Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in broiler chickens
Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in broiler chickens
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DOI：
10.3382/ps.2012-02932
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发表时间：
2013-06-01
期刊：
影响因子：
4.4
通讯作者：
Croubels, S.
中科院分区：
文献类型：
--
作者：
Watteyn, A.;Plessers, E.;Croubels, S.
Gamithromycin is a new macrolide antibiotic that is only registered for use in cattle to treat respiratory disorders such as bovine respiratory disease. The aim of this study was to determine the pharmacokinetics of gamithromycin in broiler chickens. Gamithromycin (6 mg/kg of BW) was injected intravenously (IV) or subcutaneously (SC) to six 4-wk-old chickens in a parallel study design, and blood was collected at different time points postadministration. Quantification of gamithromycin in plasma was performed using an in-house validated liquid chromatography-tandem mass spectrometry method and the pharmacokinetics analyzed according to a 2-compartmental model. Following IV administration, the mean area under the plasma concentration-time curve (AUC(0 ->infinity)), and a and beta half-life of elimination (t(1/2el alpha) and t(1/2el beta)) were 3,998 h.ng/mL, 0.90 h, and 14.12 h, respectively. Similar values were obtained after a SC bolus injection, i.e., 4,095 h.ng/mL, 0.34 h, and 11.63 h, for AUC(0 ->infinity), t(1/2el alpha), and t(1/2el beta), respectively. The mean maximum plasma concentration (889.46 ng/mL) appeared at 0.13 h. Gamithromycin showed a large volume of distribution after IV as well as SC administration, 27.08 and 20.89 L/kg, respectively, and a total body clearance of 1.61 and 1.77 L/h.kg, respectively. The absolute bioavailability was 102.4%, showing that there is a complete absorption of gamithromycin after a SC bolus injection of 6 mg/kg of BW.
