Global-local processing in schizophrenia: Hemispheric asymmetry and symptom-specific interference
Global-local processing in schizophrenia: Hemispheric asymmetry and symptom-specific interference
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DOI：
10.1017/s1355617799555069
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发表时间：
1999-07-01
影响因子：
2.6
通讯作者：
Jampala, CV
中科院分区：
文献类型：
--
作者：
Ferman, TJ;Primeau, M;Jampala, CV
精神分裂症的非典型功能半球不对称性的假设进行了测试，使用定向全球本地范式，侧化措施的视觉感知。结果表明，精神分裂症组和正常对照组的错误率较低（< 2%），但精神分裂症组的反应时间较长。在正常组中，整体和局部形式的检测速度没有差异。相比之下，精神分裂症组对局部形式的反应明显快于整体形式，这支持了精神分裂症左半球过度活跃-右半球活动不足的不对称假设。正常组表现出全局干扰效应（在存在不同的全局干扰物的情况下，对局部目标的反应潜伏期减慢）。当根据症状类型和严重程度对精神分裂症组进行检查时，高阳性症状严重程度与局部干扰（在存在不同的局部干扰物的情况下，对全局目标的反应潜伏期减慢）相关。阴性症状与来自竞争性局部或全局形式的干扰无关。高阳性和低阴性症状相结合的患者比高阴性和低阳性症状的患者表现出更大的局部干扰。相互连接的时间和额叶系统被假定为有助于这种模式的知觉处理效率和精神分裂症的分心。
The hypothesis of atypical functional hemispheric asymmetry in schizophrenia is tested using the directed global-local paradigm, a lateralizing measure of visual perception. Results indicate low error rates (< 2%) for schizophrenia and normal control groups, but longer response times for the schizophrenia group. In the normal group, detection speed of global and local forms did not differ. In contrast, the schizophrenia group responded significantly faster to local relative to global forms, which supports the asymmetry hypotheses of left hemisphere overactivity-right hemisphere underactivity in schizophrenia. The normal group exhibited a global interference effect (slowed response latency to the local target in the presence of a dissimilar global distracter). when the schizophrenia group was examined according to symptom type and severity, high positive symptom severity was associated with local interference (slowed response latency to the global target in the presence of dissimilar local distracters). Negative symptoms were not associated with interference from the competing local or global forms. Patients with a combination of high positive and low negative symptoms showed significantly greater local interference than patients with high negative and low positive symptoms. Interconnected temporal and frontal systems are postulated to contribute to this pattern of perceptual processing efficiency and distractibility in schizophrenia.