Cardiac repolarization analysis using the surface electrocardiogram
Cardiac repolarization analysis using the surface electrocardiogram
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DOI：
10.1098/rsta.2008.0230
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发表时间：
2009-01-28
期刊：
影响因子：
5
通讯作者：
Laguna, Pablo
中科院分区：
文献类型：
--
作者：
Pueyo, Esther;Martinez, Juan Pablo;Laguna, Pablo
心源性猝死（SCD）是西方世界一个具有挑战性的健康问题。根据心电图（ECG）分析心脏复极提供了有价值的信息，用于根据患者发生可能以SCD结束的心脏事件的风险对患者进行分层，以及用于评估抗心脏病治疗的疗效。在本文中，我们开始探索正常和病理条件下的心电图复极波形的细胞基础。然后，我们描述了基本的预处理步骤，需要完成的ECG信号提取复极指数之前。本文对旨在表征空间或时间复极离散度的技术进行了全面综述，并总结了其对临床风险分层的有用性。阳离子描述复极化空间离散度的技术基于复极化持续时间或T波环路形态的差异。评估复极时间离散度的技术包括分析QT间期对心率变化的适应性、QT间期和T波变异性以及T波电交替。
Sudden cardiac death (SCD) is a challenging health problem in the western world. Analysis of cardiac repolarization from the electrocardiogram ( ECG) provides valuable information for stratifying patients according to their risk of suffering from arrhythmic events that could end in SCD, as well as for assessing efficacy of antiarrhythmic therapies. In this paper, we start by exploring the cellular basis of ECG repolarization waveforms under both normal and pathological conditions. We then describe basic preprocessing steps that need to be accomplished on the ECG signal before extracting repolarization indices. A comprehensive review of techniques aimed to characterize spatial or temporal repolarization dispersion is provided, together with a summary of their usefulness for clinical risk strati. cation. Techniques that describe spatial dispersion of repolarization are based on either differences in repolarization duration or T-wave loop morphology. Techniques that evaluate temporal dispersion of repolarization include the analysis of QT interval adaptation to heart rate changes, QT interval and T-wave variability, and T-wave alternans.