INTRACRINOLOGY
INTRACRINOLOGY
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DOI：
10.1016/0303-7207(91)90116-a
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发表时间：
1991-07-01
影响因子：
4.1
通讯作者：
LABRIE, F
中科院分区：
文献类型：
--
作者：
LABRIE, F
男性中很大一部分雄激素（40%）和女性中大部分雌激素（绝经前 75%，绝经后接近 100%）是由肾上腺来源的前体类固醇在外周靶组织中合成的。编码雄激素和雌激素形成和代谢的基因在大量外周组织中表达，从而为激素作用的一个有前途的新领域（即内分泌学）提供了基础。这些类固醇生成酶和类固醇代谢酶应该成为类固醇敏感疾病（特别是乳腺癌和前列腺癌）新疗法的主要目标。
A large proportion of androgens in men (40%), and the majority of estrogens in women (75% before menopause and close to 100% after menopause), are synthesized in peripheral target tissues from precursor steroids of adrenal origin. The genes encoding the formation and metabolism of androgens and estrogens are expressed in a large series of peripheral tissues, thus providing the basis for a promising new area in hormone action, namely intracrinology. These steroidogenic and steroid metabolizing enzymes should become a major target of novel therapies for steroid-sensitive diseases, particularly breast and prostate cancer.