Activity of Protein Kinase A in the Frontal Cortex in Schizophrenia.
Activity of Protein Kinase A in the Frontal Cortex in Schizophrenia.
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DOI：
10.3390/brainsci14010013
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发表时间：
2023-12-22
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
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作者：
精神分裂症是一种严重的认知障碍，其特征是神经传递中断，这是一个需要多种激酶介导的信号事件协调的过程。有证据表明，在精神分裂症中观察到的缺陷可能是由于通过细胞内信号网络传播的激酶活性不平衡。具体而言，3′-5′-环磷酸腺苷（cAMP）相关信号通路与神经递质受体的激活偶联，并通过蛋白激酶A（PKA）的激活调节细胞功能，PKA是一种在精神分裂症额叶皮层中功能改变的酶。在这项研究中，我们测量了PKA的活性在人类死后前扣带皮层（ACC）和背外侧前额叶皮层（DLPFC）组织精神分裂症和年龄和性别匹配的对照组。PKA活性没有显着差异，观察男性和女性个体在任何大脑区域，但是，相关性分析表明，PKA活性在ACC可能会受到影响的组织pH值在所有受试者和年龄和组织pH值的女性。我们的数据提供了新的见解PKA在ACC和DLPFC精神分裂症的功能。
Schizophrenia is a serious cognitive disorder characterized by disruptions in neurotransmission, a process requiring the coordination of multiple kinase-mediated signaling events. Evidence suggests that the observed deficits in schizophrenia may be due to imbalances in kinase activity that propagate through an intracellular signaling network. Specifically, 3′-5′-cyclic adenosine monophosphate (cAMP)-associated signaling pathways are coupled to the activation of neurotransmitter receptors and modulate cellular functions through the activation of protein kinase A (PKA), an enzyme whose function is altered in the frontal cortex in schizophrenia. In this study, we measured the activity of PKA in human postmortem anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) tissue from schizophrenia and age- and sex-matched control subjects. No significant differences in PKA activity were observed in male and female individuals in either brain region; however, correlation analyses indicated that PKA activity in the ACC may be influenced by tissue pH in all subjects and by age and tissue pH in females. Our data provide novel insights into the function of PKA in the ACC and DLPFC in schizophrenia.
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影响因子：
3.7
作者：
DePasquale EAK;Alganem K;Bentea E;Nawreen N;McGuire JL;Tomar T;Naji F;Hilhorst R;Meller J;McCullumsmith RE
通讯作者：
McCullumsmith RE
影响因子：
4.5
作者：
Cherian, Kirsten;Schatzberg, Alan F.;Keller, Jennifer
通讯作者：
Keller, Jennifer
影响因子：
--
作者：
Bott A;Erdem N;Lerrer S;Hotz-Wagenblatt A;Breunig C;Abnaof K;Wörner A;Wilhelm H;Münstermann E;Ben-Baruch A;Wiemann S
通讯作者：
Wiemann S
DOI：
10.1016/j.bpsgos.2022.03.010
发表时间：
2023-07
期刊：
Biological psychiatry global open science
影响因子：
--
作者：
通讯作者：
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影响因子：
3.7
作者：
Ji L;Chauhan V;Flory MJ;Chauhan A
通讯作者：
Chauhan A