Reversible Redox of NADH and NAD+ at a Hybrid Lipid Bilayer Membrane Using Ubiquinone
Reversible Redox of NADH and NAD+ at a Hybrid Lipid Bilayer Membrane Using Ubiquinone
复制标题
DOI：
10.1021/ja204014s
复制
发表时间：
2011-08-17
影响因子：
15
通讯作者：
Chen, Hong-Yuan
中科院分区：
文献类型：
--
作者：
Ma, Wei;Li, Da-Wei;Chen, Hong-Yuan
在这里，我们报告了NADH和NAD（+）之间的可逆相互转换在一个低的超电位，这是部分介导的泛醌嵌入在仿生膜模拟呼吸的初始阶段。该系统可以作为一个平台，以检查嵌入在自然膜环境中的生物相关的电活性分子，并提供新的见解生物氧化还原循环的机制。
Here, we report the reversible interconversion between NADH and NAD(+) at a low overpotential, which is in part mediated by ubiquinone embedded in a biomimetic membrane to mimic the initial stages of respiration. This system can be used as a platform to examine biologically relevant electroactive molecules embedded in a natural membrane environment and provide new insights into the mechanism of biological redox cycling.