The role of cytokines in monocyte apoptosis
The role of cytokines in monocyte apoptosis
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DOI：
10.1159/000028082
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发表时间：
1999-01-01
期刊：
影响因子：
5
通讯作者：
Ernst, M
中科院分区：
文献类型：
--
作者：
Flad, HD;Grage-Griebenow, E;Ernst, M
Survival or apoptosis, activation and differentiation, phagocytosis and antigen presentation, migration or participation in granuloma formation are features of freshly recruited blood-borne monocytes in the local environment. In this presentation we describe that human monocytes undergo spontaneous apoptosis in vitro which involves Fas/FasL interactions, and that proinflammatory cyto kin es such as tumor necrosi a factor-alpha (TNF alpha), interteukin-1 beta and granulocyte-monocyte-colony-stimulating factor prevent spontaneous apoptosis. In vitro infection of purified monocytes with low numbers of Mycobacterium tuberculosis H37Rv prevents spontaneous apoptosis. The apoptosis-preventing effect is correlated to the release of TNF alpha and not due to phagocytosis per se. Furthermore, the minor subset of CD64-negative monocytes is found to be less susceptible to recall antigen-activated CD4-positive T cell-mediated apoptosis than CD64-positive monocytes. Finally, recent findings of our group indicate that the chemokine platelet factor 4 protects monocytes from spontaneous apoptosis and induces the differentiation of monocytes into macrophages. From these findings we conclude that monocyte recruitment, their survival, their differentiation and their functional activity at the site of inflammation are regulated by a cytokine network which needs to be further analyzed in order to design strategies for immune intervention. Copyright (C) 2000 S. Karger AG, Basel.
